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Modern embedded computing systems tend to be heterogeneous in the sense of being composed of subsystems with very different characteristics, that communicate and interact in a variety of ways—synchronous or asynchronous, buffered or unbuffered, etc. Obviously, when designing such systems, a modeling language needs to reflect this het-erogeneity. Today's(More)
We present an " opportunistic " transmission scheduling policy that exploits time-varying channel conditions and maximizes the system performance stochastically under a certain resource allocation constraint. We establish the optimality of the scheduling scheme, and also that every user experiences a performance improvement over any non-opportunistic(More)
Phenotypic modulation of vascular smooth muscle cells (VSMCs) plays a critical role in the pathogenesis of a variety of proliferative vascular diseases. Recently, we have found that microRNA (miRNA) miR-145 is the most abundant miRNA in normal vascular walls and in freshly isolated VSMCs; however, the role of miR-145 in VSMC phenotypic modulation and(More)
BACKGROUND Sirtuin 3 (SIRT3) is one of the seven mammalian sirtuins, which are homologs of the yeast Sir2 gene. SIRT3 is the only sirtuin with a reported association with the human life span. Peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) plays important roles in adaptive thermogenesis, gluconeogenesis, mitochondrial(More)
This paper presents a hierarchical hybrid system modeling and simulation framework using the Ptolemy I1 environment. Ptolemy I1 is a system-level design tool that supports the integration of multiple models of computation. The modeling of hierarchical hybrid systems is achieved by combining continuous-time models with finite state autom-ata. Breakpoint(More)
In the present study, the antidepressant-like effect of bacopaside I, a saponin compound present in the Bacopa monniera plant, was evaluated by behavioral and neurochemical methods. Bacopaside I (50, 15 and 5 mg/kg) was given to mice via oral gavage for 7 successive days. The treatment significantly decreased the immobility time in mouse models of despair(More)