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Journals and Conferences
We demonstrate a new concept of carrier-free functionalized drug nanoparticles for targeted drug delivery. It exhibits significantly enhanced drug efficacy to folate receptor-positive cells with high selectivity and a high drug loading content up to more than 78%.
Gold (Au)-nanoshelled 10-hydroxycamptothecin nanoparticles (HCPT NPs) are developed with combination of photothermal therapy and chemotherapy for highly effective cancer therapy. The strong near-infrared (NIR) absorbance from Au nanoshells endows the nanocomposites photothermal effects and on-demand drug release. Notably, the drug-loading content reaches up… (More)
We report a new strategy of using carrier-free pure near-infrared (NIR) dye nanoparticles (NPs) to achieve highly luminescent NIR fluorescent probes for in vitro and in vivo imaging. Bis(4-(N-(2-naphthyl)phenylamino) phenyl)-fumaronitrile (NPAPF) NPs are shown to exhibit favorable biocompatibility, wide-range pH stability (pH 4-10) and much more superior… (More)
Combination of chemotherapy and photothermal therapy is considered to be a promising strategy for the next generation of cancer treatments. However, it has been limited by difficulties in obtaining high drug payload chemo-photothermal agents, and thus complete destruction of tumor without recurrence has never been achieved, unless they are conjugated with… (More)
Near-infrared (NIR) fluorescence imaging in the 700-1000 nm wavelength range has been very attractive for early detection of cancers. Conventional NIR dyes often suffer from limitation of low brightness due to self-quenching, insufficient photo- and bioenvironmental stability, and small Stokes shift. Herein, we present a strategy of using small-molecule… (More)
We developed core-shell silica-coated dye nanoparticles as highly bright and ultrastable red-emitting fluorescent probes for long-term cellular imaging and ultrasensitive in vivo animal imaging.
A new strategy is presented for using doped small-molecule organic nanoparticles (NPs) to achieve high-performance fluorescent probes with strong brightness, large Stokes shifts and tunable emissions for in vitro and in vivo imaging. The host organic NPs are used not only as carriers to encapsulate different doped dyes, but also as fluorescence resonance… (More)
Pursuing higher speed of digital signal processing is the non-stop goal for human. When digital filter has been chosen, how to upgrade the speed of filter signal processing is a challenge for software engineer. This paper analyzes the techniques of sliding window and pipeline, and illustrates the application with two order Butterworth filter as an example.… (More)
We developed different-shaped drug nanocrystals with similar hydrodynamic sizes and surface charges, and found that nanorods exhibited much higher in vitro and in vivo anticancer efficacy than that of nanospheres.
When facing complex electromagnetic environment, especially strong interfering signals existing, the equipment using frequency always show some unexpected characteristics, such as sensitivity descent, some strange frequencies signals radiating which should not exist. By injection test of some electronic devices, nonlinear effects are proved to be the reason… (More)