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  • X Li, C Benjamin Ma, +6 authors S Majumdar
  • Osteoarthritis and cartilage
  • 2007
OBJECTIVE Evaluation and treatment of patients with early stages of osteoarthritis (OA) is dependent upon an accurate assessment of the cartilage lesions. However, standard cartilage dedicated magnetic resonance (MR) techniques are inconclusive in quantifying early degenerative changes. The objective of this study was to determine the ability of MR T1rho(More)
PIP2;1 is an integral membrane protein that facilitates water transport across plasma membranes. To address the dynamics of Arabidopsis thaliana PIP2;1 at the single-molecule level as well as their role in PIP2;1 regulation, we tracked green fluorescent protein-PIP2;1 molecules by variable-angle evanescent wave microscopy and fluorescence correlation(More)
Although seed germination is a major subject in plant physiological research, there is still a long way to go to elucidate the mechanism of seed germination. Recently, functional genomic strategies have been applied to study the germination of plant seeds. Here, we conducted a proteomic analysis of seed germination in rice (Oryza sativa indica cv. 9311) - a(More)
MYB transcription factor genes play important roles in many developmental processes and in various defence responses of plants. Two Arabidopsis R2R3-type MYB genes, AtMYB59 and AtMYB48, were found to undergo similar alternative splicing. Both genes have four distinctively spliced transcripts that encode either MYB-related proteins or R2R3-MYB proteins. An(More)
MYB transcription factors play important roles in many plant developmental processes and various defense responses. Two groups of MYB transcription factors were found to share a W/Y-MDDIW motif. This motif alone shows no trans-activation activity in yeast, however, it enhances the trans-activation activity of the neighbor regions greatly. We further show(More)
(1) To assess the degree of focal cartilage abnormalities in physically active and sedentary healthy subjects as well as in patients with early osteoarthritis (OA). (2) To determine the diagnostic value of T2 and T1rho measurements in identifying asymptomatic physically active subjects with focal cartilage lesions. Thirteen asymptomatic physically active(More)
Evaluation of glycosaminoglycan (GAG) concentration in articular cartilage is of particular interest to the study of degenerative joint diseases such as osteoarthritis (OA). Noninvasive imaging techniques such as magnetic resonance imaging (MRI) and computed tomography (CT) have demonstrated the potential to assess biochemical markers of cartilage integrity(More)
PURPOSE To prospectively evaluate differences in T1(rho) (T1 relaxation time in the rotating frame) and T2 values in the meniscus at magnetic resonance (MR) imaging in both patients with varying degrees of osteoarthritis (OA) and healthy control subjects. MATERIALS AND METHODS The study was institutional review board approved and HIPAA compliant. Written(More)
PURPOSE To compare vertebral bone marrow fat content quantified with proton MR spectroscopy ((1)H-MRS) with the volume of abdominal adipose tissue, lumbar spine volumetric bone mineral density (vBMD), and blood biomarkers in postmenopausal women with and without type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS Thirteen postmenopausal women with T2DM(More)
OBJECTIVE To evaluate trabecular bone structure in relationship with cartilage parameters in distal femur and proximal tibia of the human knee at 3Tesla (3T) using high-resolution magnetic resonance imaging (MRI) with parallel imaging. METHOD Sixteen healthy controls and 16 patients with mild osteoarthritis (OA) were studied using a 3T magnetic resonance(More)