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There is increasing evidence that age at menarche has decreased in Europe and the United States during the last century and in Japan over the last several decades. Data from a community-based survey conducted in two rural counties of Anhui Province in China indicate a similar, downward secular trend in age at menarche for Chinese women. The present study(More)
Tissue morphogenesis requires proper interaction between cells and the extracellular matrix (ECM), which is mediated by alphabeta heterodimeric receptor integrin. In Caenorhabditis elegans, integrin signaling is essential for formation of gonad. Here, we probe the role of several integrin-associated molecules in ovulation and cell migration. Function of(More)
The present study was to determine the role of the type I isoform of cGMP-dependent protein kinase (PKG I) and its downstream effector myosin phosphatase target subunit 1 (MYPT1) in the responses of different sized coronary arteries to nitrovasodilators. Relaxations of isolated porcine coronary arteries were determined by isometric tension recording(More)
We study minimax robust designs for response prediction and extrapolation in biased linear regression models. We extend previous work of others by considering a nonlinear fitted regression response, by taking a rather general extrapolation space and, most significantly, by dropping all restrictions on the structure of the regressors. Several examples are(More)
We discuss robust designs for generalized linear models with protection for possible departures from the usual model assumptions. Besides possible inaccuracy in an assumed linear predictor, both problems of overdispersion and misspecification in link function are addressed. For logistic and Poisson models, as examples, we incorporate the variance function(More)
BACKGROUND Vessel tension can be modulated by phosphoinositide 3-kinase (PI3K) acting on l-type calcium channel, rho kinase and phosphodiesterase (PDE) type 3 in smooth muscle cells. Inhibition of PI3K could increase the relaxation of porcine coronary arteries to nitroglycerin independent of this pathway, and the aim of the present study was therefore to(More)
Germline mutations in LKB1 result in Peutz-Jeghers Syndrome characterized by intestinal hamartomas and increased incidence of epithelial cancers. LKB1 encodes a serine/threonine kinase that plays an important role in regulating energy metabolism through the AMPK/mTOR signaling pathway. In addition, LKB1 is homologous to PAR-4, a polarity protein first(More)
Two-dimensional (2-D) inverse synthetic aperture radar (ISAR) imaging has been widely used in target scattering diagnosis, modeling and target identification. A major shortcoming is that a 2-D ISAR image cannot provide information on the relative altitude of each scattering center on the target. In this paper, we present an interferometric inverse synthetic(More)
LKB1 is a Ser/Thr kinase that plays an important role in controlling both energy metabolism and cell polarity in metazoan organisms. LKB1 is also a tumor suppressor, and homozygous, inactivating mutations are found in a wide range of human cancers. In lung cancer, inactivating mutations are found in 10 to 50% of cases, but the consequences of functional(More)
Resolution enhancement techniques in radar imaging have attracted considerable interest in recent years. In this work, we develop an iterative sidelobe apodization technique and investigate its applications to synthetic aperture radar (SAR) and inverse SAR (ISAR) image processing. A modified noninteger Nyquist spatially variant apodization (SVA) formulation(More)