Xiaohui Yuan

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Orphan nuclear receptors have been instrumental in identifying novel signaling pathways and therapeutic targets. However, identification of ligands for these receptors has often been based on random compound screens or other biased approaches. As a result, it remains unclear in many cases if the reported ligands are the true endogenous ligands,--i.e., the(More)
The major maturity gene E1 has the most prominent effect on flowering time and photoperiod sensitivity of soybean, but the pathway mediated by E1 is largely unknown. Here, we found the expression of GmFT4, a homolog of Flowering Locus T, was strongly up-regulated in transgenic soybean overexpressing E1, whereas expression of flowering activators, GmFT2a and(More)
Study of eye-movement is being employed in Human Computer Interaction (HCI) research. Eye gaze tracking is one of the most challenging problems in the area of computer vision. The goal of this paper is to present a review of latest research in this continued growth of remote eye-gaze tracking. This overview includes the basic definitions and terminologies,(More)
Soybean (Glycine max) cultivars adapted to high latitudes have a weakened or absent sensitivity to photoperiod. The purposes of this study were to determine the molecular basis for photoperiod insensitivity in various soybean accessions, focusing on the sequence diversity of the E4 (GmphyA2) gene, which encodes a phytochrome A (phyA) protein, and OPEN(More)
BACKGROUND Steady laminar flow is atheroprotective, in part because of its antiinflammatory effects on vascular endothelial cells (ECs). We studied the activation of peroxisome proliferator-activated receptor-gamma (PPARgamma) in ECs in response to laminar flow and the associated antiinflammatory effect. METHODS AND RESULTS Using flow channel with(More)
The hexon protein of human adenovirus (HAdV) processes type-specific B-cell neutralizing epitopes. We developed a new effective, reliable approach to map these epitopes on hexon protein of HAdVs. A three-dimensional (3D) model of the HAdV3 hexon was obtained by homology modeling and refined by molecular mechanics and molecular dynamics simulations. A(More)
Reviewing medical videos for the presence of disease signs presents a unique problem to the conventional image classification tasks. The learning process based on imbalanced data set is heavily biased and tends to result in low sensitivity. In this article, we present a classification method for finding video frames that contain bleeding lesions. Our method(More)