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- Publications
- Influence
Tobacco mosaic virus (TMV) inhibitors from Picrasma quassioides Benn.
- J. Chen, Xiaohui Yan, +5 authors Xiaojiang Hao
- Biology, Medicine
- Journal of agricultural and food chemistry
- 12 August 2009
To investigate natural inhibitors against tobacco mosaic virus (TMV) from plants, 10 known beta-carboline alkaloids and one quassinoid have been isolated from MeOH extract of the wood of Picrasma… Expand
Eudesmanolides from Wedelia trilobata (L.) Hitchc. as potential inducers of plant systemic acquired resistance.
- Yating Li, X. Hao, +6 authors Shunlin Li
- Biology, Medicine
- Journal of agricultural and food chemistry
- 12 April 2013
Ten eudesmanolides (1-10) including five new ones (1-4 and 6) were isolated from the whole plant of Wedelia trilobata (L.) Hitchc., a notoriously invasive weed in South China. As main constituents of… Expand
Cloning and Heterologous Expression of Three Type II PKS Gene Clusters from Streptomyces bottropensis
- Xiaohui Yan, Katharina Probst, +4 authors A. Bechthold
- Biology, Medicine
- Chembiochem : a European journal of chemical…
- 23 January 2012
Mensacarcin is a potent cytotoxic agent isolated from Streptomyces bottropensis. It possesses a high content of oxygen atoms and two epoxide groups, and shows cytostatic and cytotoxic activity… Expand
Dihydropyrimidine-Thiones and Clioquinol Synergize To Target β-Amyloid Cellular Pathologies through a Metal-Dependent Mechanism.
- Daniel F. Tardiff, L. Brown, +7 authors S. Lindquist
- Biology, Medicine
- ACS chemical neuroscience
- 12 July 2017
The lack of therapies for neurodegenerative diseases arises from our incomplete understanding of their underlying cellular toxicities and the limited number of predictive model systems. It is… Expand
Huanglongmycin A-C, Cytotoxic Polyketides Biosynthesized by a Putative Type II Polyketide Synthase From Streptomyces sp. CB09001
Three natural products of nonaketide biosynthetic origin, probably biosynthesized from nine molecules of malonyl-CoA, have been isolated. Herein we described the isolation and structure elucidation… Expand
Enediynes: Exploration of Microbial Genomics to Discover New Anticancer Drug Leads
- B. Shen, Hindra Hindra, +6 authors J. Lohman
- Chemistry
- 1 February 2015
TorsinA rescues ER-associated stress and locomotive defects in C. elegans models of ALS
- Michelle L. Thompson, P. Chen, +5 authors G. Caldwell
- Biology
- Journal of Cell Science
- 15 February 2014
Arctigenin alleviates TGF-β1-induced epithelial-mesenchymal transition and PAI-1 expression via AMPK/NF-κB pathway in peritoneal mesothelial cells.
- Gang Jin, Yanjin Su, Q. Dong, Xiaohong Zhao, L. Zhang, Xiaohui Yan
- Chemistry, Medicine
- Biochemical and biophysical research…
- 3 December 2019
Peritoneal fibrosis (PF) caused by long-term peritoneal dialysis is closely associated with the epithelial-mesenchymal transition (EMT) of human peritoneal mesothelial cells (HPMCs). Moreover, the… Expand
PBK promotes aggressive phenotypes of cervical cancer through ERK/c-Myc signaling pathway.
Cervical cancer is the fourth most frequent cancer in women worldwide. PDZ-binding kinase (PBK) is proven to promote the malignant behaviors of various carcinomas. However, its functional roles and… Expand
Early Steps in the Biosynthetic Pathway of Rishirilide B
- Philipp Schwarzer, O. Tsypik, +8 authors Andreas Bechthold
- Chemistry, Medicine
- Molecules
- 1 April 2020
The biological active compound rishirilide B is produced by Streptomyces bottropensis. The cosmid cos4 contains the complete rishirilide B biosynthesis gene cluster. Its heterologous expression in… Expand