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Increasingly, 802.11 devices are being used by mobile users. This results in very dynamic wireless channels that are difficult to use efficiently. Current rate selection algorithms are dominated by probe-based approaches that search for the best transmission rate using trial-and-error. In mobile environments, probe-based techniques often perform poorly(More)
Next-generation sequencing technology is a powerful tool for transcriptome analysis. However, under certain conditions, only a small amount of material is available, which requires more sensitive techniques that can preferably be used at the single-cell level. Here we describe a single-cell digital gene expression profiling assay. Using our mRNA-Seq assay(More)
Target predictions and validations are major obstacles facing microRNA (miRNA) researchers. Animal miRNA target prediction is challenging because of limited miRNA sequence complementarity to the targets. In addition, only a small number of predicted targets have been experimentally validated and the miRNA mechanism is poorly understood. Here we present a(More)
Opioids create a neuroinflammatory response within the CNS, compromising opioid-induced analgesia and contributing to various unwanted actions. How this occurs is unknown but has been assumed to be via classic opioid receptors. Herein, we provide direct evidence that morphine creates neuroinflammation via the activation of an innate immune receptor and not(More)
Can we understand van Gogh's mood from his artworks? For many years, people have tried to capture van Gogh's affects from his artworks so as to understand the essential meaning behind the images and catch on why van Gogh created these works. In this paper, we study the problem of inferring affects from images in social networks. In particular, we aim to(More)
The CFTR chloride channel is activated by phosphorylation of serine residues in the regulatory (R) domain and then gated by ATP binding and hydrolysis at the nucleotide binding domains (NBDs). Studies of the ATP-dependent gating process in excised inside-out patches are very often hampered by channel rundown partly caused by membrane-associated(More)
The vertebrate Apolipoprotein D (ApoD) is a lipocalin secreted from subsets of neurons and glia during neural development and aging . A strong correlation exists between ApoD overexpression and numerous nervous system pathologies as well as obesity, diabetes, and many forms of cancer . However, the exact relationship between the function of ApoD and the(More)
BACKGROUND Variants of microRNAs (miRNAs), called isomiRs, are commonly reported in deep-sequencing studies; however, the functional significance of these variants remains controversial. Observational studies show that isomiR patterns are non-random, hinting that these molecules could be regulated and therefore functional, although no conclusive biological(More)
The need for more realistic and richer forms of assessment i n educational tests has led to the inclusion (in many tests) of polytomously scored items, multiple items based on a single stimulus (a "testlet"), and the increased use of a generalized mixture of binary and polytomous item formats. In this paper we extend earlier work (Bradlow, Wainer & Wang,(More)
One critical step in RNA interference (RNAi) experiments is to design small interfering RNAs (siRNAs) that can greatly reduce the expression of the target transcripts, but not of other unintended targets. Although various statistical and computational approaches have been attempted, this remains a challenge facing RNAi researchers. Here, we present a new(More)