Intracerebral haemorrhage (ICH) is a subtype of stroke that associated with neurological dysfunction and inflammation, which may be ameliorated by a neuroprotective strategy targeting the complement… (More)
Anti-tumour necrosis factor (TNF) monoclonal antibody (mAb) (infliximab, IFX) has been shown to be highly effective in the management of Crohn's disease (CD). Herein we investigated the potential… (More)
AIM
To explore the effect of immunization with copolymer-1 (COP-1) and retinal stem cells (RSCs) transplantation on interferon-gamma (IFN-γ) levels in a rat experimental glaucoma model.
METHODS
An… (More)
AIM
To evaluate the influence of hydrogen peroxide (H(2)O(2)) on mouse photoreceptor-derived 661W cell survival and to determine the effect of PD98059, an inhibitor for MEK1 (the direct upstream… (More)
AIM
To determine whether small interfering RNA (siRNA) of PGC-1α could inhibit vascular endothelial growth factor (VEGF) expression and tube formation in human retinal vascular endothelial cells… (More)
OBJECTIVES
To investigate the effect of miRNA-128b on apoptosis and the Bcl-2 and Caspase 3 expression in rat middle cerebral artery occlusion (MCAO) model.
METHODS
The MCAO model was established… (More)
The objective of this study was to investigate the possibility of increasing the remote patency rate of allogeneic vessel transplantation through studying the effects of… (More)
Objective: There has been an increasing interest in recent years in the role of stem cells. With an extensive understanding of their biology, a major role for stem cells in the malignant process has… (More)
OBJECTIVE
To explore the effect of HIF-1α specific siRNA expression vector pSUPERH1-siHIF-1α on retinal neovascularization in a mouse model of retinopathy of prematurity (ROP).
METHODS
Forty-eight… (More)