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Neuroprotective effects of argatroban and C5a receptor antagonist (PMX53) following intracerebral haemorrhage.

• Guoxin Li, R-M Fan, +7 authors Shuzhong Yao
• Clinical and experimental immunology
• 2014

Intracerebral haemorrhage (ICH) is a subtype of stroke that associated with neurological dysfunction and inflammation, which may be ameliorated by a neuroprotective strategy targeting the complement… (More)

Anti-tumour necrosis factor therapy enhances mucosal healing through down-regulation of interleukin-21 expression and T helper type 17 cell infiltration in Crohn's disease.

• Chao Liu, Xiaohua Xia, +7 authors Z-Q Liu
• Clinical and experimental immunology
• 2013

Anti-tumour necrosis factor (TNF) monoclonal antibody (mAb) (infliximab, IFX) has been shown to be highly effective in the management of Crohn's disease (CD). Herein we investigated the potential… (More)

Retinal stem cells transplantation combined with copolymer-1 immunization reduces interferon-gamma levels in an experimental model of glaucoma.

• Xiaomin Zhou, Xiaohua Xia
• International journal of ophthalmology
• 2011

AIM To explore the effect of immunization with copolymer-1 (COP-1) and retinal stem cells (RSCs) transplantation on interferon-gamma (IFN-γ) levels in a rat experimental glaucoma model. METHODS An… (More)

Activation of the ERK 1/2 and STAT3 signaling pathways is required for 661W cell survival following oxidant injury.

• Shu-Qian Dong, Hui-zhuo Xu, Xiaohua Xia, Sha Wang, Li-xin Zhang, Shuang-zhen Liu
• International journal of ophthalmology
• 2012

AIM To evaluate the influence of hydrogen peroxide (H(2)O(2)) on mouse photoreceptor-derived 661W cell survival and to determine the effect of PD98059, an inhibitor for MEK1 (the direct upstream… (More)

Small interfering RNA targeting PGC-1α inhibits VEGF expression and tube formation in human retinal vascular endothelial cells.

• Jian Jiang, Lu Zhang, Xiaohua Xia
• International journal of ophthalmology
• 2015

AIM To determine whether small interfering RNA (siRNA) of PGC-1α could inhibit vascular endothelial growth factor (VEGF) expression and tube formation in human retinal vascular endothelial cells… (More)

miRNA-128b promotes cerebral infarction by regulating the expressions of Bcl-2 and Caspase 3.

• Jin Ma, Lei Bao, +4 authors Zhenyu Cao
• World neurosurgery
• 2018

OBJECTIVES To investigate the effect of miRNA-128b on apoptosis and the Bcl-2 and Caspase 3 expression in rat middle cerebral artery occlusion (MCAO) model. METHODS The MCAO model was established… (More)

Effects of EDC-PEI heparinization on allogeneic vascular antigens and inflammation levels via a rat abdominal aorta transplantation model

• Fangzheng Han, Puxun Tian, +6 authors Chenguang Ding
• Experimental and therapeutic medicine
• 2018

The objective of this study was to investigate the possibility of increasing the remote patency rate of allogeneic vessel transplantation through studying the effects of… (More)

Identification and Characterization of Side Population Cells in Human Lung Adenocarcinoma SPCA 1 Cells

• Yan-liang Zhu, Long-bang Chen, Jing-hua Wang, Xiaohua Xia
• 2012

Objective: There has been an increasing interest in recent years in the role of stem cells. With an extensive understanding of their biology, a major role for stem cells in the malignant process has… (More)

HIF-1α siRNA reduces retinal neovascularization in a mouse model of retinopathy of prematurity.

• Hui-zhuo Xu, Shuang-zhen Liu, Si-qi Xiong, Xiaohua Xia
• Translational pediatrics
• 2013

OBJECTIVE To explore the effect of HIF-1α specific siRNA expression vector pSUPERH1-siHIF-1α on retinal neovascularization in a mouse model of retinopathy of prematurity (ROP). METHODS Forty-eight… (More)

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