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The genome of Mesobuthus martensii reveals a unique adaptation model of arthropods
The genome sequence of Mesobuthus martensii is reported, containing 32,016 protein-coding genes, the most among sequenced arthropods, and reveals a unique adaptation model of arthropod, offering new insights into the genetic bases of the living fossils.
DLP1‐dependent mitochondrial fragmentation mediates 1‐methyl‐4‐phenylpyridinium toxicity in neurons: implications for Parkinson’s disease
Findings suggest that DLP1‐dependent mitochondrial fragmentation plays a crucial role in mediating MPP+‐induced mitochondria abnormalities and cellular dysfunction and may represent a novel therapeutic target for PD.
Increased Basal Synaptic Inhibition of Hippocampal Area CA1 Pyramidal Neurons by an Antiepileptic Drug that Enhances IH
Examination of the effects of LTG on IH and spontaneous firing of area CA1 stratum oriens interneurons, as well as on spontaneous inhibitory postsynaptic currents in CA1 pyramidal neurons in immature rat brain slices, indicates that IH inCA1 interneURons can be increased by LTG, that Ih enhancement increases interneuron excitability, and that these effects are associated with increased basal synaptic inhibition ofCA1 pyramsidal neurons.
Development of Viral Vectors for Gene Therapy for Chronic Pain
Several promising viral vectors that could be applied in gene transfer for the treatment of chronic pain are reviewed and the possible mechanisms of genes of interest that can be delivered with viral vectors are discussed.
MicroRNA-503 acts as a tumor suppressor in glioblastoma for multiple antitumor effects by targeting IGF-1R
The results demonstrated that overexpression of miR-503 in GBM cell lines not only suppressed cell proliferation through inducing G0/G1 cell cycle arrest and apoptosis, but also inhibited cancer cell migration and tumor invasion.
Adeno-associated virus type 5 reduces learning deficits and restores glutamate receptor subunit levels in MPS VII mice CNS.
It is demonstrated that AAV5 vectors deliver a therapeutically effective beta-glucuronidase gene to the CNS and a possible mechanism underlying spatial learning defects in MPS VII mice is suggested.
Interaction of Thiamine Deficiency and Voluntary Alcohol Consumption Disrupts Rat Corpus Callosum Ultrastructure
The graded abnormalities across the dually to singly treated animals support a compounding effect of alcohol exposure andThiamine depletion, and indicate the potential for interaction between alcohol and thiamine deficiency in human alcohol-related brain damage.
Influence of orientation and temperature on the fatigue crack growth of a nickel-based directionally solidified superalloy
Abstract Fatigue crack growth (FCG) behaviors of a widely used nickel-based directionally solidified (DS) superalloy have been investigated. Standard compact tension (CT) specimens in longitudinal,
MiR-873 acts as a novel sensitizer of glioma cells to cisplatin by targeting Bcl-2.
It is found that many miRNAs, including miR‑873, are differentially expressed in cisplatin-resistant glioma cells compared to wild-type gliomas cells and that re-expression of Bcl-2 attenuated the function of miR-873 in cisPlatin- resistant gli cancer cells and the sensitivity of the cells to cis Platin.
2S albumin gene expression in castor plant (Ricinus communis L.)
Protein domain sequence analysis revealed that castor 2S albumin contains the trypsin/α-amylase inhibitor family domain, suggesting a role for the albumin in insect resistance.