Xiaohong Zhou

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Genetic screens using Saccharomyces cerevisiae have identified an array of cytosolic Hsp70 mutants that are impaired in the ability to propagate the yeast [PSI(+)] prion. The best characterized of these mutants is the Ssa1 L483W mutant (so-called SSA1-21), which is located in the substrate-binding domain of the protein. However, biochemical analysis of some(More)
This paper investigates the shortest paths tree problem taking single link failure into account. Let G be a graph modeled by network with vertex set V and edge set E. Given a specified vertex s. A shortest paths tree T<sub>s</sub>={e<sub>1</sub>, e<sub>2</sub>, <sub>hellip</sub>, e<sub>n-1</sub>} rooted at s satisfies the path from s to u<sub>i</sub> in(More)
This paper studies the optimal path cover problem in graphs of small treewidth. Let G=(V, E) be a graph modeled by network with vertex set V and edge set E. Given a specified vertex set S<sub>V</sub>subeV(G), a path cover is a path P of G such that S<sub>V</sub>subeV(P). A path cover PC is optimal if the cost of PC is minimum. Optimal path cover problem is(More)
Alkaline phosphatase (ALP) is an important diagnostic indicator of many human diseases. To quantitatively track ALP in biosystems, herein, for the first time, we report an efficient two-photon ratiometric fluorescent probe, termed probe 1 and based on classic naphthalene derivatives with a donor-π-acceptor (D-π-A) structure and deprotection of the(More)
Photoactivatable fluorophores have become an important technique for the high spatiotemporal resolution of biological imaging. Here, we developed a novel photoactivatable probe (PHBT), which is based on 2-(2-hydroxyphenyl)benzothiazole (HBT), a small organic fluorophore known for its classic luminescence mechanism through excited-state intramolecular proton(More)
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