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Cyclins are primary regulators of the activity of cyclin-dependent kinases, which are known to play critical roles in controlling eukaryotic cell cycle progression. While there has been extensive research on cell cycle mechanisms and cyclin function in animals and yeasts, only a small number of plant cyclins have been characterized functionally. In this(More)
Since the first report of p53 as a non-histone target of a histone acetyltransferase (HAT), there has been a rapid proliferation in the description of new non-histone targets of HATs. Of these, transcription factors comprise the largest class of new targets. The substrates for HATs extend to cytoskeletal proteins, molecular chaperones and nuclear import(More)
We applied a comprehensive data-mining strategy to examine the repertoires of rat and mouse odorant receptors (ORs) and type 1 pheromone receptors (V1Rs) using the mm5 (mouse) and rn3 (rat) genomes. We identified 1576 rat OR genes, including 292 pseudogenes. The rat V1R repertoire is composed of 115 intact genes and 72 pseudogenes. The mouse OR and V1R(More)
Histone deacetylase 6 (HDAC6) is a tubulin-specific deacetylase that regulates microtubule-dependent cell movement. In this study, we identify the F-actin-binding protein cortactin as a HDAC6 substrate. We demonstrate that HDAC6 binds cortactin and that overexpression of HDAC6 leads to hypoacetylation of cortactin, whereas inhibition of HDAC6 activity leads(More)
The large number of olfactory receptor genes necessitates high throughput methods to analyze their expression patterns. We have therefore designed a high-density oligonucleotide array containing all known mouse olfactory receptor (OR) and V1R vomeronasal receptor genes. This custom array detected a large number of receptor genes, demonstrating specific(More)
In this paper, a new corner detector is proposed based on evolution difference of scale pace, which can well reflect the change of the domination feature between the evolved curves. In Gaussian scale space we use Difference of Gaussian (DoG) to represent these scale evolution differences of planar curves and the response function of the corners is defined(More)
Data locality has recently been extensively exploited in Cloud computing to improve system performance. However, when schedule Map tasks in Hadoop MapReduce framework working in a heterogeneous environment, existing methods either cannot reduce the occurrence of these Map tasks or injure fairness, thus degrading the system performance. In order to address(More)
An efficient and novel technique is developed for detecting and localizing corners of planar curves. This paper discusses the gradient feature distribution of planar curves and constructs gradient correlation matrices (GCMs) over the region of support (ROS) of these planar curves. It is shown that the eigen-structure and determinant of the GCMs encode the(More)
OBJECTIVE To report the performance of massively parallel sequencing (MPS) based prenatal noninvasive fetal trisomy test based on cell-free DNA sequencing from maternal plasma in a routine clinical setting in China. METHOD The MPS-based test was offered as a prenatal screening test for trisomies 21 and 18 to pregnant women in 49 medical centers over 2(More)