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With traffic carried by fiber access networks continuously increasing, the survivability and scalability of networks have become critical for their applicability. In this paper, a low-redundancy passive optical network (PON) architecture using a star-cross-bus topology is presented along with a scale-differentiated, centrally controlled hybrid failure(More)
It is well documented that protein kinase A (PKA) acts as a negative regulator of M phase promoting factor (MPF) by phosphorylating cell division cycle 25 homolog B (Cdc25B) in mammals. However, the molecular mechanism remains unclear. In this study, we identified PKA phosphorylation sites in vitro by LC-MS/MS analysis, including Ser(149), Ser(229), and(More)
BACKGROUND Acute lymphoblastic leukemia (ALL) is a common hematological malignant neoplasm that typically affects children. Although intense chemotherapeutic regimens have been useful to combat the disease, approximately 20% of patients will relapse despite treatment. Diagnosing ALL requires bone marrow puncture procedure, which many parents do not consent(More)
The ubiquitin-specific protease Usp7 plays roles in multiple cellular processes through deubiquitinating and stabilizing numerous substrates, including P53, Pten and Gli. Aberrant Usp7 activity has been implicated in many disorders and tumorigenesis, making it as a potential target for therapeutic intervention. Although it is clear that Usp7 is involved in(More)
Optical burst switching networks have been receiving much attention as a promising approach to build the nextgeneration optical Internet. In this paper, we firstly describe the basic architecture of the optical burst switching network (OBS) based on dynamic wavelength routing (DWR), under which the guarantee of the quality of service (QoS) in the DWR-OBS(More)
Hollow porous gold nanoparticles (HPGNPs) were synthesized via a one-step solution phase method at ambient temperature. The particle size, ranging from 80nm to 350nm, was easily controlled by changing the concentration of HAuCl4. The morphology and the structure of the as-prepared HPGNPs were investigated by SEM, TEM, HRTEM and XPS. Langmuir isotherm(More)
Based on a multimode interference (MMI) coupler in slot waveguide structures, an ultracompact wavelength demultiplexer operating at 1.30 and 1.55mum wavelengths is proposed and designed by using a full-vector mapped Galerkin mode solver and a modified three-dimensional full-vector beam propagation method. The tapered waveguide structures are applied to(More)
A design scheme for silicon-based slot-waveguide crossing using a slot-to-strip mode converter (at each port) and a strip-multimode-waveguide (SMW) crossing is proposed. The guided modes of the input slot-waveguide are first efficiently transformed into that of the single-mode strip waveguide by using the mode converter, and then enter into the SMW, where(More)
MicroRNAs (miRNAs) play an indispensable role in cancer initiation and progression. Different cancers have some common hallmarks in general. Analyzing miRNAs that consistently contribute to different cancers can help us to discover the relationship between miRNAs and traits shared by cancers. Most previous works focus on analyzing single miRNA. However,(More)