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Sepsis is characterized by uncontrolled inflammatory responses. Macrophage migration inhibitory factor (MIF) has been shown to play an important role in the progression of sepsis thus is a potential therapeutic target. The aim of this study is to produce IgG anti-MIF monoclonal antibodies (mAbs) with anti-septic abilities in vivo and to determine mechanisms(More)
This paper describes a methodology based on genetic algorithms for the solution of inverse problems pertaining to the identiication of aw shapes and the reconstruction of boundary conditions in a continua. Such problems often arise in scientiic research or engineering practice. By using a genetic algorithm we avoid the weakness of the traditional gradient(More)
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