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Regulation of TRAIL Expression by the Phosphatidylinositol 3-Kinase/Akt/GSK-3 Pathway in Human Colon Cancer Cells*
- Qingding Wang, Xiaofu Wang, Ambrosio Hernandez, M. Hellmich, Z. Gatalica, B. Evers
- Biology, ChemistryThe Journal of Biological Chemistry
- 27 September 2002
Results identify TRAIL, a novel TNF family member, as a downstream target of the PI 3-kinase/Akt/GSK-3 pathway and may have important implications for better understanding the role of thePI 3- Kinase pathway in intestinal cell homeostasis.
mTORC1 inhibition increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON.
- Jing Li, Jianyu Liu, B. Evers
- Biology, ChemistryAmerican journal of physiology. Cell physiology
- 20 April 2011
A physiological link between mTORC1 and MEK/ERK signaling in controlling intestinal hormone gene expression and secretion is identified and activation of mTOR in BON cells treated with amino acids, high glucose, or serum is shown.
Curcumin Inhibits Neurotensin-Mediated Interleukin-8 Production and Migration of HCT116 Human Colon Cancer Cells
- Xiaofu Wang, Qingding Wang, K. Ives, B. Evers
- Biology, MedicineClinical Cancer Research
- 15 September 2006
A potential mechanism for the chemopreventive and chemotherapeutic effects of curcumin on colon cancers may be through the inhibition of gastrointestinal hormone (e.g., neurotensin)–induced chemokine expression and cell migration.
Triptolide inhibits proliferation and migration of colon cancer cells by inhibition of cell cycle regulators and cytokine receptors.
Augmentation of sodium butyrate-induced apoptosis by phosphatidylinositol 3'-kinase inhibition in the KM20 human colon cancer cell line.
- Qingding Wang, Nan Li, Xiaofu Wang, M. M. Kim, B. Evers
- BiologyClinical cancer research : an official journal of…
- 1 June 2002
These findings suggest that agents that selectively target the PI3k pathway may enhance the effects of standard chemotherapeutic agents and provide novel adjuvant treatment for selected colon cancers.
Regulation of phorbol ester-mediated TRAF1 induction in human colon cancer cells through a PKC/RAF/ERK/NF-κB-dependent pathway
The results demonstrate selective induction of TRAF1 in human colon cancer cells through a Ca2+-dependent PKC/Raf-1/ERK/NF-κB-dependent pathway.
An integrated analysis for long noncoding RNAs and microRNAs with the mediated competing endogenous RNA network in papillary renal cell carcinoma
From these results, it is believed that the identified ceRNA network plays a crucial role in the process of PRCC deterioration, and some of the identified genes are strongly related to clinical prognosis.
Induction of cIAP-2 in human colon cancer cells through PKC delta/NF-kappa B.
A role for a PKC/NF-kappa B-dependent pathway in the regulation of cIAP-2 expression in human colon cancer cells is demonstrated and data suggest a novel mechanism for the anti-apoptotic function mediated by the PKC delta/ NF- kappa B/cI AP-2 pathway in certain cancers.
Curcumin inhibits proliferation of colorectal carcinoma by modulating Akt/mTOR signaling.
The data suggest that curcumin, a natural compound, may exert its antiproliferative effects by inhibition of mTOR signaling and thus may represent a novel class of m TOR inhibitor.