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INO80 facilitates pluripotency gene activation in embryonic stem cell self-renewal, reprogramming, and blastocyst development.
This work defines a requirement for the INO80 complex, a SWI/SNF family chromatin remodeler, in ESC self-renewal, somatic cell reprogramming, and blastocyst development and reveals an essential role for Ino80 in the expression of the pluripotency network. Expand
TRIM28 regulates RNA polymerase II promoter proximal pausing and pause release
- Heeyoun Bunch, Xiaofeng Zheng, +9 authors S. Calderwood
- Biology, Medicine
- Nature Structural &Molecular Biology
- 1 April 2014
In vivo and in vitro mechanistic studies suggest that transcription-coupled phosphorylation regulates Pol II pause release by TRIM28, which is identified as a new factor that modulates Pol II pausing and transcriptional elongation at a large number of mammalian genes. Expand
Fip1 regulates mRNA alternative polyadenylation to promote stem cell self‐renewal
It is shown that an mRNA 3′ processing factor, Fip1, is essential for embryonic stem cell self‐renewal and somatic cell reprogramming and mechanistic insight is provided on APA regulation in development and an important function for APA in cell fate specification is established. Expand
The THO complex regulates pluripotency gene mRNA export and controls embryonic stem cell self-renewal and somatic cell reprogramming.
It is shown that THO preferentially interacts with pluripotency gene transcripts through Thoc5 and is required for self-renewal at least in part by regulating their export and expression, and therefore a role for this aspect of posttranscriptional regulation in stem cell fate specification is uncovered. Expand
Cnot1, Cnot2, and Cnot3 Maintain Mouse and Human ESC Identity and Inhibit Extraembryonic Differentiation
The results indicate that Cnot1, Cnot2, and Cnot3 represent a novel component of the core self‐renewal and pluripotency circuitry conserved in mouse and human ESCs. Expand
Transcription coactivator Cited1 acts as an inducer of trophoblast-like state from mouse embryonic stem cells through the activation of BMP signaling
It is reported that Cited1, a transcription coactivator, is a robust inducer for trophoblast-like state from mouse embryonic stem cells (ESCs). Expand
RNA polymerase II promoter-proximal pausing in mammalian long non-coding genes.
The genomic study has shown that a significant number of long non-coding RNAs (lncRNAs, >1000 nucleotides) harbor RNA polymerase II (Pol II) engaged with the transcriptional start site, suggesting an important role of Pol II pausing for the transcription of mammalian lncRNA genes. Expand
The anterior chamber of the eye is a transplantation site that supports and enables visualisation of beta cell development in mice
- Yusuf Ali, Juan A. Diez, Lars Selander, Xiaofeng Zheng, H. Edlund, P. Berggren
- Biology, Medicine
- 4 February 2016
It is shown that the anterior chamber of the eye (ACE) is able to support growth, differentiation and function of a developing pancreatic bud across time in vivo. Expand
CNOT3-Dependent mRNA Deadenylation Safeguards the Pluripotent State
It is proposed that CNOT3 maintains the pluripotent state by promoting differentiation gene mRNA deadenylation and degradation, and poly(A) tail-length regulation is identified as a post-transcriptional mechanism that controls pluripotency. Expand
Depletion of hCINAP by RNA interference causes defects in Cajal body formation, histone transcription, and cell viability
- Jinfang Zhang, Feiyun Zhang, Xiaofeng Zheng
- Biology, Medicine
- Cellular and Molecular Life Sciences
- 26 February 2010
Investigation of increased caspase-3 activities in hCINAP-depleted cells indicate that apoptosis is one of the reasons for the loss of viability and data suggest that hCinAP is essential for the formation of canonical CBs, histone transcription, and cell viability. Expand