Xiaofeng Dou

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Mycoepoxydiene (MED) is a polyketide isolated from the marine fungal Diaporthe sp. HLY-1 associated with mangroves. Although MED has been shown to have various biological effects such as antimicrobial, anti-cancer, and anti-inflammatory activities, its activities and cellular mechanisms during microglial activation have yet to be elucidated. In the present(More)
Neuropilin-1 (NRP-1) is a nontyrosine kinase coreceptor for semaphorin 3A and the vascular endothelial growth factor involved in tumor angiogenesis, growth, and metastasis and is regarded as a promising target for cancer therapy. In the present study, we investigated the effects of an anti-NRP-1 monoclonal antibody (mAb) that we generated for MCF7 breast(More)
As a co-receptor for vascular endothelial growth factor (VEGF), Neuropilin-1 (NRP-1) plays an important role in angiogenesis and malignant progression of many human cancers. However, the role of NRP-1 in hepatocellular carcinoma (HCC) is not well understood. The study aimed to detected the expression of Neuropilin-1 in HCC and investigate the association(More)
in his paper, the configuration characteristic of shunt active power filter (APF) was analyzed, as well as the adaptive linear neural network. In order to improve the dynamic performance of a control system and estimate harmonic distortion from nonlinear load current, a combination strategy based on the Fourier series analysis of the current signals and LMS(More)
Naked2 (NKD2) is a member of the Naked family and negatively regulates canonical Wnt signaling. NKD2 may play a role in embryo development and tumor formation by affecting Wnt signaling. In the present study, we describe the establishment of a monoclonal antibody against NKD2 (anti-NKD2 MAb) through the hybridoma method. The purified anti-NKD2 MAb measured(More)
OBJECTIVE To evaluate the effect of translocator protein (TSPO, Mr 18 000) on the productions of TNF-α, IL-1β and IL-6 in lipopolysaccharide (LPS)-stimulated BV-2 cells. METHODS RNA interference technique was used to decrease TSPO expression in BV-2 cells. Western blotting was performed to assess the level of TSPO protein in BV-2 cells transfected with(More)
As a novel co-receptor for vascular endothelial growth factor (VEGF), neuropilin receptor type-1 (NRP-1) is overexpressed in several cancers and metastases, and serves as an attractive target for cancer molecular imaging and therapy. Previous single photon emission computerized tomography (SPECT) studies demonstrated that the small NRP-1-targeting peptides(More)
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