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Tissue-Specific Immunopathology in Fatal COVID-19
- D. Dorward, C. Russell, C. Lucas
- Medicine, BiologyAmerican journal of respiratory and critical care…
- 20 November 2020
Tissue-specific immunopathology occurs in COVID-19, implicating a significant component of the immune-mediated, virus-independent immunopathologic process as a primary mechanism in severe disease.
Comparison of rhesus and cynomolgus macaques as an infection model for COVID-19
It is shown that SARS-CoV-2 replicates in the upper and lower respiratory tract and causes pulmonary lesions in both rhesus and cynomolgus macaques, and a new method for lung histopathology scoring is described that will provide a metric to enable clearer decision making for this key endpoint.
Meloxicam suppresses hepatocellular carcinoma cell proliferation and migration by targeting COX-2/PGE2-regulated activation of the β-catenin signaling pathway.
It is found that meloxicam inhibited HCC cell proliferation and had a cell cycle arrest effect in human HCC cells, and these findings provide a new treatment strategy against HCC proliferation and migration.
Genomes of trombidid mites reveal novel predicted allergens and laterally transferred genes associated with secondary metabolism
The first trombidid mites genomes, obtained both for a chigger, Leptotrombidium deliense, and for a velvet mite, Dinothrombium tinctorium, exhibited evidence of ancient lateral gene transfer from soil-derived bacteria or fungi.
Targeting hypoxia-inducible factor-2α enhances sorafenib antitumor activity via β-catenin/C-Myc-dependent pathways in hepatocellular carcinoma.
The results demonstrated that hypoxia protected HCC cells against sorafenib; however, short hairpin RNA-HIF-2α transfection in combination with sorAFenib treatment exhibited a significantly synergistic effect against HCC cell proliferation.
T7 peptide inhibits angiogenesis via downregulation of angiopoietin-2 and autophagy.
The T7 peptide inhibited angiogenesis and exerted its antitumor effects by inhibition of Ang2, phosphorylation of AKT and matrix metalloproteinase-2 (MMP-2) regulated by Ang2 and inhibition of autophagy may significantly enhance the anti-angiogenic activity of the T6 peptide.
Downregulation of secreted clusterin potentiates the lethality of sorafenib in hepatocellular carcinoma in association with the inhibition of ERK1/2 signals.
- J. Zhong, Xiaoming Yu, Xuetao Shi
- Biology, MedicineInternational journal of molecular medicine
- 1 May 2018
The downregulation of sCLU by CLU shRNA synergistically increased SOR sensitivity in the Bel‑7402 and SMMC‑7721 cells, and potentiated SOR‑induced cell apoptosis, which indicates a novel treatment strategy for HCC.
Amplicon based MinION sequencing of SARS-CoV-2 and metagenomic characterisation of nasopharyngeal swabs from patients with COVID-19
Amplicon and metagenomic MinION based sequencing was used to rapidly identify SARS-CoV-2 and assess the microbiome in nasopharyngeal swabs obtained from patients with COVID-19 by the ISARIC 4C consortium.
MicroRNA-22 inhibits cell growth and metastasis in breast cancer via targeting of SIRT1
The results of the present study suggested that miR-22 demonstrated suppressive effects on breast cancer growth and metastasis via targeting SIRT1, and thus the miR -22/SIRT1 axis may be used as a novel and potential therapeutic target for breast cancer in the future.
Secretory clusterin contributes to oxaliplatin resistance by activating Akt pathway in hepatocellular carcinoma
SCLU contributes to OXA resistance by activating Akt pathway, indicating that sCLU may be a novel molecular target for overcoming OxA resistance in HCC.