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Tissue-Specific Immunopathology in Fatal COVID-19
TLDR
Tissue-specific immunopathology occurs in COVID-19, implicating a significant component of the immune-mediated, virus-independent immunopathologic process as a primary mechanism in severe disease.
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Comparison of rhesus and cynomolgus macaques as an infection model for COVID-19
TLDR
It is shown that SARS-CoV-2 replicates in the upper and lower respiratory tract and causes pulmonary lesions in both rhesus and cynomolgus macaques, and a new method for lung histopathology scoring is described that will provide a metric to enable clearer decision making for this key endpoint.
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Meloxicam suppresses hepatocellular carcinoma cell proliferation and migration by targeting COX-2/PGE2-regulated activation of the β-catenin signaling pathway.
TLDR
It is found that meloxicam inhibited HCC cell proliferation and had a cell cycle arrest effect in human HCC cells, and these findings provide a new treatment strategy against HCC proliferation and migration.
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Genomes of trombidid mites reveal novel predicted allergens and laterally transferred genes associated with secondary metabolism
TLDR
The first trombidid mites genomes, obtained both for a chigger, Leptotrombidium deliense, and for a velvet mite, Dinothrombium tinctorium, exhibited evidence of ancient lateral gene transfer from soil-derived bacteria or fungi.
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Targeting hypoxia-inducible factor-2α enhances sorafenib antitumor activity via β-catenin/C-Myc-dependent pathways in hepatocellular carcinoma.
TLDR
The results demonstrated that hypoxia protected HCC cells against sorafenib; however, short hairpin RNA-HIF-2α transfection in combination with sorAFenib treatment exhibited a significantly synergistic effect against HCC cell proliferation.
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T7 peptide inhibits angiogenesis via downregulation of angiopoietin-2 and autophagy.
TLDR
The T7 peptide inhibited angiogenesis and exerted its antitumor effects by inhibition of Ang2, phosphorylation of AKT and matrix metalloproteinase-2 (MMP-2) regulated by Ang2 and inhibition of autophagy may significantly enhance the anti-angiogenic activity of the T6 peptide.
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Downregulation of secreted clusterin potentiates the lethality of sorafenib in hepatocellular carcinoma in association with the inhibition of ERK1/2 signals.
TLDR
The downregulation of sCLU by CLU shRNA synergistically increased SOR sensitivity in the Bel‑7402 and SMMC‑7721 cells, and potentiated SOR‑induced cell apoptosis, which indicates a novel treatment strategy for HCC.
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Amplicon based MinION sequencing of SARS-CoV-2 and metagenomic characterisation of nasopharyngeal swabs from patients with COVID-19
TLDR
Amplicon and metagenomic MinION based sequencing was used to rapidly identify SARS-CoV-2 and assess the microbiome in nasopharyngeal swabs obtained from patients with COVID-19 by the ISARIC 4C consortium.
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MicroRNA-22 inhibits cell growth and metastasis in breast cancer via targeting of SIRT1
TLDR
The results of the present study suggested that miR-22 demonstrated suppressive effects on breast cancer growth and metastasis via targeting SIRT1, and thus the miR -22/SIRT1 axis may be used as a novel and potential therapeutic target for breast cancer in the future.
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Secretory clusterin contributes to oxaliplatin resistance by activating Akt pathway in hepatocellular carcinoma
TLDR
SCLU contributes to OXA resistance by activating Akt pathway, indicating that sCLU may be a novel molecular target for overcoming OxA resistance in HCC.
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