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Structure and Biosynthesis of Isatropolones, Bioactive Amine-Scavenging Fluorescent Natural Products from Streptomyces Gö66.
The natural products isatropolone A-C (1-3) were reisolated from Streptomyces Gö66, with 1 and 3 showing potent activity against Leishmania donovani. They contain a rare tropolone ring derived from a… Expand
Entomopathogenic bacteria use multiple mechanisms for bioactive peptide library design.
The production of natural product compound libraries has been observed in nature for different organisms such as bacteria, fungi and plants; however, little is known about the mechanisms generating… Expand
Biosynthesis of the Antibiotic Nematophin and Its Elongated Derivatives in Entomopathogenic Bacteria.
- Xiaofeng Cai, Victoria L. Challinor, +5 authors H. Bode
- Medicine, Chemistry
- Organic letters
- 30 January 2017
Nematophin, a known antibiotic natural product against Staphylococcus aureus for almost 20 years, is produced by all strains of Xenorhabdus nematophila. Despite its simple structure, its biosynthesis… Expand
Structure-based redesign of docking domain interactions modulates the product spectrum of a rhabdopeptide-synthesizing NRPS
Several peptides in clinical use are derived from non-ribosomal peptide synthetases (NRPS). In these systems multiple NRPS subunits interact with each other in a specific linear order mediated by… Expand
Struktur und Biosynthese der Isatropolone, bioaktiver und Amin-reaktiver fluoreszierender Naturstoffe aus Streptomyces Gö66
Die Naturstoffe Isatropolon A–C (1–3) wurden aus Streptomyces Go66 reisoliert, und insbesondere 1 und 3 zeigen sehr gute Aktivitat gegen Leishmania donovani. Sie tragen einen ungewohnlichen… Expand
Methionine-Containing Rhabdopeptide/Xenortide-like Peptides from Heterologous Expression of the Biosynthetic Gene Cluster kj12ABC in Escherichia coli.
- Lei Zhao, Xiaofeng Cai, M. Kaiser, H. Bode
- Biology, Medicine
- Journal of natural products
- 10 October 2018
Seven new methionine-containing rhabdopeptide/xenortide-like peptides (1-7) were identified from Escherichia coli expressing the rhabdopeptide/xenortide-like peptide biosynthetic gene cluster kj12ABC… Expand
Small RNA directs symbiosis, virulence, and natural products biosynthesis in entomopathogenic bacteria
Rapid modulation of gene expression is a key feature for the success of bacteria, particularly for those that rapidly have to adapt to different niches. The lifecycles of Photorhabdus and Xenorhabdus… Expand