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BACKGROUND Duration of effect of aesthetic treatments with botulinum toxin potentially influences subject satisfaction, treatment frequency, and annual costs, but quantitative outcomes for measuring duration of effect and correlations with subject satisfaction have yet to be fully elucidated. METHODS AND MATERIALS Phase III clinical trials with similar(More)
BACKGROUND This was the second study in a Phase 3 program treating crow's feet lines (CFL) with onabotulinumtoxinA. OBJECTIVE To evaluate the efficacy and safety of onabotulinumtoxinA treatment of CFL alone or with glabellar lines (GL). METHODS This multicenter, double-blind, placebo-controlled, repeat treatment, 7-month study randomized subjects with(More)
BACKGROUND Patterns of crow's feet lines (CFLs) vary among individuals. OBJECTIVE To characterize distribution and predictors of CFL patterns. METHODS Patterns of CFLs (full fan, lower fan, central fan, and upper fan) were evaluated at maximum smile and at rest from photographs of subjects with moderate-to-severe CFLs. Relationships between CFL pattern(More)
BACKGROUND OnabotulinumtoxinA is an established treatment for glabellar frown lines, but its effects on lines at repose are less well documented. OBJECTIVE To assess the effect of onabotulinumtoxinA on elimination of mild lines at repose. METHODS Data from two randomized, double-blind, placebo-controlled studies were included. Elimination of mild lines(More)
BACKGROUND This study was part of a Phase 3 program treating crow's feet lines (CFL) with onabotulinumtoxinA. OBJECTIVE To evaluate the efficacy and safety of onabotulinumtoxinA treatment of CFL. METHODS This multicenter, double-blind, placebo-controlled, 5-month study randomized subjects with moderate-to-severe CFL (maximum smile) to onabotulinumtoxinA(More)
BACKGROUND This is the third study in a Phase 3 program evaluating onabotulinumtoxinA treatment of crow's feet lines (CFL). OBJECTIVE To assess the efficacy and safety of repeated onabotulinumtoxinA treatments of CFL alone or with glabellar lines (GL) in subjects with moderate-to-severe CFL and GL (maximum smile). MATERIALS AND METHODS This 5-month(More)
BACKGROUND Although millions of aesthetic procedures are performed annually, few patient-reported outcome (PRO) measures have been used in this setting. OBJECTIVE To evaluate the impact of onabotulinumtoxinA treatment for crow's feet lines (CFL) on relevant psychological variables and self-perception of age/appearance in subgroup populations. MATERIALS(More)
BACKGROUND OnabotulinumtoxinA has demonstrated the ability to eliminate mild glabellar lines at rest; however, less is known regarding the effect of repeat treatment on more severe lines at rest. OBJECTIVE To assess the effect of repeated onabotulinumtoxinA treatment for reduction of glabellar lines at rest. METHODS Subjects 18 to 75 years old with at(More)
Deep processing of closed or semi-closed determines the fact that the cutting heat is not easy to diffuse; the situation of the cutting tool can not be directly observed; chips difficult to discharge, tools prone to wear and collapse, the quality of surface difficult to ensure; drills need to have sufficient rigidity, because thin-walled tubular parts tend(More)
This study evaluated the safety and efficacy of onabotulinumtoxinA in Japanese subjects with crow’s feet lines (CFL). This phase 3, multicenter, double-blind, randomized study included 2 treatment periods: 6-month placebo-controlled period followed by a 7-month open-label period. In period 1, subjects with moderate to severe CFL received onabotulinumtoxinA(More)