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— The presence of both multiple-access interference (MAI) and intersymbol interference (ISI) constitutes a major impediment to reliable communications in multipath code-division multiple-access (CDMA) channels. In this paper, an iterative receiver structure is proposed for decoding multiuser information data in a convolutionally coded asynchronous multipath(More)
The Biological General Repository for Interaction Datasets (BioGRID) is a public database that archives and disseminates genetic and protein interaction data from model organisms and humans (http://www.thebiogrid.org). BioGRID currently holds 347,966 interactions (170,162 genetic, 177,804 protein) curated from both high-throughput data sets and individual(More)
To meet the needs of wireless broadband access, the IEEE 802.16 protocol for wireless metropolitan networks (WirelessMAN) has been recently standardized. The medium access control (MAC) layer of the IEEE 802.16 has point-to-multipoint (PMP) mode and mesh mode. Previous works on the IEEE 802.16 have primarily focused on the PMP mode. In the mesh mode, all(More)
Smac mimetics induce apoptosis synergistically with TNF-alpha by triggering the formation of a caspase-8-activating complex containing receptor interacting protein kinase-1 (RIPK1). Caspase inhibitors block this form of apoptosis in many types of cells. However, in several other cell lines, caspase inhibitors switch the apoptotic response to necrosis. A(More)
The receptor-interacting serine-threonine kinase 3 (RIP3) is a key signaling molecule in the programmed necrosis (necroptosis) pathway. This pathway plays important roles in a variety of physiological and pathological conditions, including development, tissue damage response, and antiviral immunity. Here, we report the identification of a small molecule(More)
The inflammatory response of mammalian cells to TNF-alpha can be switched to apoptosis either by cotreatment with a protein synthesis inhibitor, cycloheximide, or Smac mimetic, a small molecule mimic of Smac/Diablo protein. Cycloheximide promotes caspase-8 activation by eliminating endogenous caspase-8 inhibitor, c-FLIP, while Smac mimetic does so by(More)
— The problem of blind demodulation of multiuser information symbols in a high-rate code-division multiple-access (CDMA) network in the presence of both multiple-access interference (MAI) and intersymbol interference (ISI) is considered. The dispersive CDMA channel is first cast into a multiple-input multiple-output (MIMO) signal model framework. By(More)
The RNA interference (RNAi) pathway is initiated by processing long double-stranded RNA into small interfering RNA (siRNA). The siRNA-generating enzyme was purified from Drosophila S2cells and consists of two stoichiometric subunits: Dicer-2(DCR-2) and a previously unknown protein that we named R2D2. R2D2 is homologous to the Caenorhabditis elegans RNAi(More)
— The CSMA/CA protocols are designed under the assumption that all participant nodes would abide to the protocol rules. This is of particular importance in distributed protocols such as the IEEE 802.11 distributed coordinating function (DCF), in which nodes control their own backoff parameters. In this work, we propose a method to detect selfish misbehaving(More)