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Triterpenoids and Limonoids from Dysoxylum lukii with Cytotoxic and Antimicrobial Activities
A phytochemical investigation of a 70 % ethanol extract of the stem bark of Dysoxylum lukii has resulted in the isolation of eight new tirucallane-type triterpenoids, one new limonoid, and five knownExpand
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Curcumin protects SH-SY5Y cells from oxidative stress by up-regulating HO-1 via Phosphatidylinositol 3 Kinase/Akt/Nrf-2 and down-regulating HO-2
Background Oxidative stress is considered to have a causative role in the development of central nervous system diseases, such as Alzheimer’s disease, Parkinson’s disease, tumor, etc. Curcumin, aExpand
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Glycyrrhetinic acid alleviates hepatic inflammation injury in viral hepatitis disease via a HMGB1-TLR4 signaling pathway
Abstract Various human disorders are cured by the use of licorice, a key ingredient of herbal remedies. Glycyrrhizic acid (GL), a triterpenoid glycoside, is the aqueous extract from licoriceExpand
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The hepatitis C virus protein NS3 suppresses TNF-α–stimulated activation of NF-κB by targeting LUBAC
A hepatitis C virus protein blocks NF-κB activation to suppress the antiviral immune response. How HCV suppresses NF-κB activation The inflammatory cytokine TNF-α induces antiviral immune responsesExpand
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Evidence for tight junction protein disruption in intestinal mucosa of malignant obstructive jaundice patients
Abstract Objective. Experimental and clinical studies have shown that obstructive jaundice results in increased intestinal permeability. The mechanisms implicated in this phenomenon remain obscure.Expand
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First small-molecule PROTACs for G protein-coupled receptors: inducing α1A-adrenergic receptor degradation
Proteolysis targeting chimeras (PROTACs) are dual-functional hybrid molecules that can selectively recruit an E3 ubiquitin ligase to a target protein to direct the protein into theExpand
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Correction: A siRNA-induced peptide co-assembly system as a peptide-based siRNA nanocarrier for cancer therapy
Correction for ‘A siRNA-induced peptide co-assembly system as a peptide-based siRNA nanocarrier for cancer therapy’ by Wenjun Li et al., Mater. Horiz., 2018, 5, 745–752.
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EVALUATION OF ANTI-CANCER ACTIVITY OF SURVIVIN siRNA DELIVERED BY FOLATE RECEPTOR-TARGETED POLYETHYLENE-GLYCOL LIPOSOMES IN K562-BEARING XENOGRAFT MICE
Objective: To investigate anti-cancer activity of the novel survivin siRNA Folate Receptor (FR)-targeted Polyethylene-Glycol Liposomes (PEG) liposomes in K562-bearing nude mice. Methods: The leukemiaExpand
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RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation
Significance RIG-I, an up-regulated gene in ATRA-induced myeloid differentiation of APL cells, has been repeatedly described as a cytoplasmic RNA receptor that plays a vital role in the innateExpand
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Effects of over‐expression of HIF‐1alpha in bone marrow‐derived mesenchymal stem cells on traumatic brain injury
Mesenchymal stem cells (MSCs) have been shown to play therapeutic effect in traumatic brain injury (TBI). To augment the therapeutic effect, MSCs could be engineered to over‐express genes that areExpand
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