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- Publications
- Influence
Triterpenoids and Limonoids from Dysoxylum lukii with Cytotoxic and Antimicrobial Activities
- J. Hu, X. Wang, Xiaodong Shi
- Chemistry
- 1 December 2011
A phytochemical investigation of a 70 % ethanol extract of the stem bark of Dysoxylum lukii has resulted in the isolation of eight new tirucallane-type triterpenoids, one new limonoid, and five known… Expand
Curcumin protects SH-SY5Y cells from oxidative stress by up-regulating HO-1 via Phosphatidylinositol 3 Kinase/Akt/Nrf-2 and down-regulating HO-2
- Wenke Yin, X. Zhang, Xiaodong Shi, Y. Li
- Medicine
- Molecular Neurodegeneration
- 7 February 2012
Background Oxidative stress is considered to have a causative role in the development of central nervous system diseases, such as Alzheimer’s disease, Parkinson’s disease, tumor, etc. Curcumin, a… Expand
Glycyrrhetinic acid alleviates hepatic inflammation injury in viral hepatitis disease via a HMGB1-TLR4 signaling pathway
- Xiaodong Shi, L. Yu, +5 authors P. Du
- Medicine
- International Immunopharmacology
- 8 May 2020
Abstract
Various human disorders are cured by the use of licorice, a key ingredient of herbal remedies. Glycyrrhizic acid (GL), a triterpenoid glycoside, is the aqueous extract from licorice… Expand
The hepatitis C virus protein NS3 suppresses TNF-α–stimulated activation of NF-κB by targeting LUBAC
- YongZhi Chen, L. He, +6 authors H. Deng
- Biology, Medicine
- Science Signaling
- 17 November 2015
A hepatitis C virus protein blocks NF-κB activation to suppress the antiviral immune response. How HCV suppresses NF-κB activation The inflammatory cytokine TNF-α induces antiviral immune responses… Expand
Evidence for tight junction protein disruption in intestinal mucosa of malignant obstructive jaundice patients
- N. Wang, Huiling Yu, +5 authors H. Jiang
- Biology, Medicine
- Scandinavian journal of gastroenterology
- 23 January 2010
Abstract Objective. Experimental and clinical studies have shown that obstructive jaundice results in increased intestinal permeability. The mechanisms implicated in this phenomenon remain obscure.… Expand
First small-molecule PROTACs for G protein-coupled receptors: inducing α1A-adrenergic receptor degradation
- Z. Li, Yuxing Lin, +9 authors M. Li
- Chemistry, Medicine
- Acta pharmaceutica Sinica. B
- 27 January 2020
Proteolysis targeting chimeras (PROTACs) are dual-functional hybrid molecules that can selectively recruit an E3 ubiquitin ligase to a target protein to direct the protein into the… Expand
Correction: A siRNA-induced peptide co-assembly system as a peptide-based siRNA nanocarrier for cancer therapy
- W. Li, Dongyuan Wang, +9 authors Z. Li
- Chemistry
- 8 July 2019
Correction for ‘A siRNA-induced peptide co-assembly system as a peptide-based siRNA nanocarrier for cancer therapy’ by Wenjun Li et al., Mater. Horiz., 2018, 5, 745–752.
EVALUATION OF ANTI-CANCER ACTIVITY OF SURVIVIN siRNA DELIVERED BY FOLATE RECEPTOR-TARGETED POLYETHYLENE-GLYCOL LIPOSOMES IN K562-BEARING XENOGRAFT MICE
Objective: To investigate anti-cancer activity of the novel survivin siRNA Folate Receptor (FR)-targeted Polyethylene-Glycol Liposomes (PEG) liposomes in K562-bearing nude mice. Methods: The leukemia… Expand
RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation
- Song-Fang Wu, L. Xia, +12 authors Saijuan Chen
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 8 June 2020
Significance RIG-I, an up-regulated gene in ATRA-induced myeloid differentiation of APL cells, has been repeatedly described as a cytoplasmic RNA receptor that plays a vital role in the innate… Expand
Effects of over‐expression of HIF‐1alpha in bone marrow‐derived mesenchymal stem cells on traumatic brain injury
- Xiaodong Shi, G. Zhang, +4 authors H. Xiao
- Medicine
- Engineering in life sciences
- 14 April 2018
Mesenchymal stem cells (MSCs) have been shown to play therapeutic effect in traumatic brain injury (TBI). To augment the therapeutic effect, MSCs could be engineered to over‐express genes that are… Expand