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BACKGROUND The interleukin-28B gene (IL28B) locus has been associated with host resistance to hepatitis C virus (HCV) infection and response to PEG-IFN/RBV treatment in western populations. This study was to determine whether this gene variant is also associated with spontaneous clearance of HCV infection, treatment response and IL-28B protein production in(More)
This paper describes the internal working of a novel UNL converter for the Chinese language. Three steps are involved in generating Chinese from UNL: first, the UNL expression is converted to a graph; second, the graph is converted to a number of trees. Third, a top-down tree walking is performed to translate each subtree and the results are composed to(More)
Neural machine translation (NMT) heavily relies on word-level modelling to learn semantic representations of input sentences. However, for languages without natural word delimiters (e.g., Chi-nese) where input sentences have to be to-kenized first, conventional NMT is confronted with two issues: 1) it is difficult to find an optimal tokenization granularity(More)
BACKGROUND AND AIM The prevalence of the hepatitis B virus (HBV) is higher in adults than in children. We determined the seroepidemiology of HBV infection in an adult population in JiLin, China, to guide effective preventive measures. METHODS A cross-sectional serosurvey was conducted throughout JiLin, China. A total of 3833 people was selected and(More)
BACKGROUND T follicular helper (TFH) cells are a special subpopulation of T helper cells and can regulate humoral immune responses. This study examined whether the frequency of CD4(+)CXCR5(+) TFH cells could be associated with active immunity in chronic hepatitis B (CHB) patients. METHODOLOGY AND FINDINGS The frequencies of peripheral blood CD4(+)CXCR5(+)(More)
As ubiquitous molecular chaperones, small heat shock proteins (sHSPs) are crucial for protein homeostasis. It is not clear why sHSPs are able to bind a wide spectrum of non-native substrate proteins and how such binding is enhanced by heat shock. Here, by utilizing a genetically incorporated photo-cross-linker (p-benzoyl-l-phenylalanine), we systematically(More)
Neural stem cells are self-renewing, multipotent and undifferentiated precursors that retain the capacity for differentiation into both glial (astrocytes and oligodendrocytes) and neuronal lineages. Neural stem cells offer cell-based therapies for neurological disorders such as Alzheimer's disease, Parkinson's disease, Huntington's disease and spinal cord(More)
This study was designed to detect miR-575 expression and function in non-small cell lung cancer (NSCLC). A higher expression of miR-575 in NSCLC tissues was observed compared with adjacent non-neoplastic tissues. Furthermore, re-introduction of miR-575 significantly promoted cell proliferation, migration, and invasion in the NSCLC line. Moreover, we showed(More)
OBJECTIVE Experimental and clinical studies have shown that obstructive jaundice results in increased intestinal permeability. The mechanisms implicated in this phenomenon remain obscure. Integrated tight junctions (TJs) are essential for normal gut barrier function. TJ proteins, such as zonula occludens (ZO)-1, claudins and occludin, are indispensable to(More)
BACKGROUND Recent genome-wide association studies found that genetic polymorphisms near the IL28B gene is strongly associated with sustained viral response and spontaneous viral clearance in chronically infected hepatitis C patients. AIMS We aimed to evaluate the effects of IL28B variations on hepatitis B virus (HBV) infection in a Chinese Han population(More)