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BACKGROUND The interleukin-28B gene (IL28B) locus has been associated with host resistance to hepatitis C virus (HCV) infection and response to PEG-IFN/RBV treatment in western populations. This study was to determine whether this gene variant is also associated with spontaneous clearance of HCV infection, treatment response and IL-28B protein production in(More)
This paper describes the internal working of a novel UNL converter for the Chinese language. Three steps are involved in generating Chinese from UNL: first, the UNL expression is converted to a graph; second, the graph is converted to a number of trees. Third, a top-down tree walking is performed to translate each subtree and the results are composed to(More)
BACKGROUND AND AIM The prevalence of the hepatitis B virus (HBV) is higher in adults than in children. We determined the seroepidemiology of HBV infection in an adult population in JiLin, China, to guide effective preventive measures. METHODS A cross-sectional serosurvey was conducted throughout JiLin, China. A total of 3833 people was selected and(More)
As ubiquitous molecular chaperones, small heat shock proteins (sHSPs) are crucial for protein homeostasis. It is not clear why sHSPs are able to bind a wide spectrum of non-native substrate proteins and how such binding is enhanced by heat shock. Here, by utilizing a genetically incorporated photo-cross-linker (p-benzoyl-l-phenylalanine), we systematically(More)
Neural machine translation (NMT) heavily relies on word-level modelling to learn semantic representations of input sentences. However, for languages without natural word delimiters (e.g., Chi-nese) where input sentences have to be to-kenized first, conventional NMT is confronted with two issues: 1) it is difficult to find an optimal tokenization granularity(More)
This study was designed to detect miR-575 expression and function in non-small cell lung cancer (NSCLC). A higher expression of miR-575 in NSCLC tissues was observed compared with adjacent non-neoplastic tissues. Furthermore, re-introduction of miR-575 significantly promoted cell proliferation, migration, and invasion in the NSCLC line. Moreover, we showed(More)
BACKGROUND Recent genome-wide association studies found that genetic polymorphisms near the IL28B gene is strongly associated with sustained viral response and spontaneous viral clearance in chronically infected hepatitis C patients. AIMS We aimed to evaluate the effects of IL28B variations on hepatitis B virus (HBV) infection in a Chinese Han population(More)
OBJECTIVE Experimental and clinical studies have shown that obstructive jaundice results in increased intestinal permeability. The mechanisms implicated in this phenomenon remain obscure. Integrated tight junctions (TJs) are essential for normal gut barrier function. TJ proteins, such as zonula occludens (ZO)-1, claudins and occludin, are indispensable to(More)
TNF-α and its two receptors (TNFR1 and 2) are known to stimulate dendritic cell (DC) maturation and T cell response. However, the specific receptor and mechanisms involved in vivo are still controversial. In this study, we show that in response to an attenuated mouse hepatitis virus infection, DCs fail to mobilize and up-regulate CD40, CD80, CD86, and MHC(More)