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BACKGROUND Cardiac progenitor cells (CPCs) have been proven suitable for stem cell therapy after myocardial infarction, especially c-kit(+)CPCs. CPCs marker c-kit and its ligand, the stem cell factor (SCF), are linked as c-kit/SCF axis, which is associated with the functions of proliferation and differentiation. In our previous study, we found that stromal(More)
—Live migration of virtual machines has been a powerful tool to facilitate system maintenance, load balancing, fault tolerance, and power-saving, especially in clusters or data centers. Although pre-copy is a predominantly used approach in the state of the art, it is difficult to provide quick migration with low network overhead, due to a great amount of(More)
• To the best of our knowledge, we are the first to exploit memory compression technique to minimize the downtime and total migration time of live migration. • By analyzing memory page characteristics, we implement an adaptive memory compression approach to tune migration performance of virtual machines. A zero-aware characteristics-based compression (CBC)(More)
Limited by the existing design pattern, a lot of existing softwares have not yet taken full use of multicore processing power, incurring low utilization of hardware, even a bottleneck of the whole system. To address this problem, in this paper, we propose a VM-based Web system on multicore clusters. The VM-based Web system is scheduled by Linux Virtual(More)
BACKGROUND Familial hypercholesterolemia (FH) is an autosomal dominant disease that primarily results from mutations in the low-density lipoprotein receptor (LDLR) gene. We investigated two unrelated Chinese FH patients using gene screening and functional analysis to reveal the pathogenicity and the mechanism by which these mutations cause FH. METHODS(More)
Alzheimer's disease (AD) is characterized by early impairments in memory and progressive neurodegeneration. Disruption of synaptic plasticity processes that underlie learning and memory contribute partly to this pathophysiology. Tripchlorolide (T4 ), an extract from a traditional Chinese herbal Tripterygium wilfordii Hook F, has been shown to be(More)
Transforming growth factor-beta (TGF-β), a key mediator of cardiac fibroblast activation, has a major influence on collagen type I production. However, the epigenetic mechanisms by which TGF-β induces collagen type I alpha 1 (COL1A1) expression are not fully understood. This study was designed to examine whether or not DNA methylation is involved in(More)
Sperm-associated antigen 9 (SPAG9) is a recently characterized oncoprotein involved in the progression of several human malignancies. The present study aims to investigate the expression pattern and biological roles of SPAG9 protein in human astrocytoma. SPAG9 expression was analyzed in 105 astrocytoma specimens by immunohistochemistry. We observed negative(More)
Growing evidence has demonstrated that maternal detrimental factors, including inflammation, contribute to the development of hypertension in the offspring. The current study found that offspring subjected to prenatal exposure of inflammation by lipopolysaccharide (LPS) challenge during the second semester showed significantly increased systolic blood(More)
Prenatal exposure to an inflammatory stimulus has been shown to cause renal damage in offspring. Our present study explored the role of intra-renal NF-κB activation in the development of progressive renal fibrosis in offspring that underwent prenatal exposure to an inflammatory stimulus. Time-dated pregnant rats were treated with saline (control group) or(More)