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Extracellular pH is usually low in solid tumors, in contrast to the approximately neutral intracellular pH. V-ATPase, which overly functions in some cancers with metastatic potential, plays an important role in maintaining neutral cytosolic pH, very acidic luminal pH, and acidic extracellular pH. ATP6L, the 16 kDa subunit of proton pump V-ATPase, can(More)
Endophytic fungi are known to play important ecological roles in protecting plants from various abiotic and biotic stresses. Therefore, it is valuable to investigate the endophytic fungal community associated with plants distributed in harsh environments, such as deserts. Fungal communities in the stems and leaves of ten plant samples belonging to eight(More)
Bromodomain-containing protein Brd4 is shown to persistently associate with chromosomes during mitosis for transmitting epigenetic memory across cell divisions. During interphase, Brd4 also plays a key role in regulating the transcription of signal-inducible genes by recruiting positive transcription elongation factor b (P-TEFb) to promoters. How the(More)
A new image segmentation algorithm based on Markov random field (MRF) and ant colony system (ACS) is presented in this paper. Information positive feedback and heuristic search, the characters of ACS, were applied for the image segmentations with MRF model. The maximum a posterior (MAP) global best solution of segmentations will be got though MRF, which(More)
In order to meet the heterogeneous requirements from service providers and users simultaneously, there is an urgent need for a new information service system. After studying the characteristics of the users' accessing, that popularity of information utilization generally exists in information system is focused. This paper introduces a rating oriented(More)
During cotranslational protein targeting by the signal recognition particle (SRP), information about signal sequence binding in the SRP's M domain must be effectively communicated to its GTPase domain to turn on its interaction with the SRP receptor (SR) and thus deliver the cargo proteins to the membrane. A universally conserved "fingerloop" lines the(More)
Despite being extensively characterized structurally and biochemically, the functional role of histone deacetylase 8 (HDAC8) has remained largely obscure due in part to a lack of known cellular substrates. Herein, we describe an unbiased approach using chemical tools in conjunction with sophisticated proteomics methods to identify novel non-histone nuclear(More)
Transcription elongation has been recognized as a rate-limiting step for the expression of signal-inducible genes. Through recruitment of positive transcription elongation factor P-TEFb, the bromodomain-containing protein BRD4 plays critical roles in regulating the transcription elongation of a vast array of inducible genes that are important for multiple(More)