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We provided evidence for the formation of a novel phospholipase C-mediated calcium signal arising from coactivation of D1 and D2 dopamine receptors. In the present study, robust fluorescence resonance energy transfer showed that these receptors exist in close proximity indicative of D1-D2 receptor heterooligomerization. The close proximity of these(More)
D(1) and D(2) dopamine receptors exist as heteromers in cells and brain tissue and are dynamically regulated and separated by agonist concentrations at the cell surface. We determined that these receptor pairs interact primarily through discrete amino acids in the cytoplasmic regions of each receptor, with no evidence of any D(1)-D(2) receptor transmembrane(More)
As a ubiquitous phenomenon in communication networks, the self-similar nature of network traffic has recently received great interests and been extensively studied. In this paper, assuming the buffering capability of the source node, through combining the traffic properties and channel characteristics, we analyze the queuing behaviors of self-similar(More)
Multi-cell transmission in single frequency networks (SFN)area for MBMS can be used to improve the system performance. This paper proposes a novel Virtual Hybrid Automatic Repeat Request(V-HARQ) mechanism for multi-cell MBMS transmission in the UMTS networks, by which multiple signals like the retransmission versions of HARQ mechanism in unicast mode from(More)
With the rapid development of the mobile wireless system, the operator is experiencing unprecedented challenges on service maintenance and operational expenditure, which drives the demand for realizing automation in current networks. The cell outage detection is considered as an effective way to automatically detect network fault. Our work presents an(More)
Multiple input multiple output (MIMO) system with large number of antennas, referred to as massive MIMO, has drawn increasing attention for it enables very high throughput in LTE-Advanced networks. Massive MIMO arrays are expected to be implemented in a three dimensional (3D) array structure and 3D MIMO is introduced. Antenna propagation was considered only(More)
We have demonstrated that D(5) and D(2) dopamine receptors exist as heteromers in cells, and determined these receptor interact through amino acids in the cytoplasmic regions of each receptor. Specifically involved in heteromer formation we identified in the carboxyl tail of the D(5) receptor three adjacent glutamic acid residues, and in intracellular loop(More)