• Publications
  • Influence
Regulation and function of the RSK family of protein kinases.
TLDR
The structure, expression and activation mechanisms of the RSK isoforms are reviewed, and their physiological roles on the basis of established substrates and recent discoveries are discussed, increasing the diversity of biological functions regulated by RSK. Expand
RSK phosphorylates SOS1 creating 14-3-3-docking sites and negatively regulating MAPK activation.
TLDR
Using biochemical, pharmacological and quantitative MS approaches, it is shown that RSK phosphorylates the Ras activator SOS1 (Son of Sevenless homologue 1) in cultured cells on two C-terminal residues, Ser( 1134) and Ser(1161), and that R SK-dependent SOS1 phosphorylation creates 14-3-3 binding sites. Expand
MiR-34b-5p Suppresses Melanoma Differentiation-Associated Gene 5 (MDA5) Signaling Pathway to Promote Avian Leukosis Virus Subgroup J (ALV-J)-Infected Cells Proliferaction and ALV-J Replication
TLDR
It is suggested that miR-34b-5p targets MDA5 to accelerate the proliferation and migration of ALV-J-infected cells, and it promotes ALv-J replication, via the Mda5 signaling pathway. Expand
Gab2 Phosphorylation by RSK Inhibits Shp2 Recruitment and Cell Motility
TLDR
It is demonstrated that activation of the Ras/mitogen-activated protein kinase (MAPK) pathway promotes Gab2 phosphorylation on basic consensus motifs, and it is suggested that RSK is part of a negative-feedback loop that restricts Gab2-dependent epithelial cell motility. Expand
CD274 promotes cell cycle entry of leukemia-initiating cells through JNK/Cyclin D2 signaling
TLDR
The surface immune molecule CD274 plays a critical role in the proliferation of LICs and was directly associated with JNK and enhanced the downstream signaling to increase the Cyclin D2 level, promoting leukemia development. Expand
Metabolic Imaging Reveals a Unique Preference of Symmetric Cell Division and Homing of Leukemia-Initiating Cells in an Endosteal Niche.
TLDR
SoNar-high human leukemia cells or primary samples have enhanced clonogenic capacities in vitro or leukemogenesis in  vivo, and PDK2 fine-tunes glycolysis, homing, and symmetric division of LICs. Expand
Extracellular Signal-Regulated Kinases 1 and 2 Phosphorylate Gab2 To Promote a Negative-Feedback Loop That Attenuates Phosphoinositide 3-Kinase/Akt Signaling
TLDR
It is shown that Gab2 becomes phosphorylated on multiple proline-directed sites upon stimulation of the Ras/extracellular signal-regulated kinase (ERK) signaling pathway and that ERK1/2 participates in a negative-feedback loop that attenuates PI3K/Akt signaling in response to various agonists. Expand
Cellular and molecular evidence for malignancy-inhibitory functions of p15RS
TLDR
It is indicated that p15RS has malignancy inhibitory functions independent of cell cycle inhibition and provide novel insights on the role of p15 in tumor inhibition. Expand
Observations on the ultrastructure of extrusomes in the hypotrichous ciliate Architricha indica (Protist, Ciliophora)
TLDR
The results showed that the mature extrusomes of Architricha indica were ellipsoidal vesicles with structureless cavities on their anterior parts and arranged in rows beneath the pellicle; the extruded structures of extrusome were cyathiform and can remain outside of the cell surface after extrusion. Expand
MiR-34b-5p Mediates the Proliferation and Differentiation of Myoblasts by Targeting IGFBP2
TLDR
Results indicate that miR-34b-5p could mediate the proliferation and differentiation of myoblasts by targeting IGFBP2. Expand
...
1
2
3
...