Share This Author
The establishment and biological assessment of a whole tissue-engineered intervertebral disc with PBST fibers and a chitosan hydrogel in vitro and in vivo.
- Dechao Yuan, Zhu Chen, G. Feng
- Biology, EngineeringJournal of biomedical materials research. Part B…
- 1 October 2019
The whole TE-IVD has biological and biomechanical properties to some extent, which is a promising candidate for IVD replacement therapies.
Tex10 is upregulated and promotes cancer stem cell properties and chemoresistance in hepatocellular carcinoma
This study demonstrates that Tex10 plays a potent carcinogenic role in HCC tumorigenesis by maintaining cancer stem cell properties through activation of the STAT3 signaling pathway and promoting chemo-resistance.
Functional evidence that the self-renewal gene NANOG regulates esophageal squamous cancer development.
Fabrication of a Cu/Zn co-incorporated calcium phosphate scaffold-derived GDF-5 sustained release system with enhanced angiogenesis and osteogenesis properties
In vitro co-culture of bone mesenchymal stem cells and vascular endothelial cells showed that the addition of Cu/Zn ions and GDF-5 in the BCP scaffold not only accelerated cell proliferation, but also promoted cell differentiation by enhancing the alkaline phosphatase activity and bone-related gene expression.
Tex10 promotes stemness and EMT phenotypes in esophageal squamous cell carcinoma via the Wnt/β-catenin pathway
The findings of the present study suggest that the downregulation of Tex10 in ESCC specimens is significantly associated with tumor malignancy, and that Tex10 promotes stem cell-like features and induces the EMT of ESCC cells through the enhancement of Wnt/β-catenin signaling.
Fangchinoline exerts anticancer effects on colorectal cancer by inducing autophagy via regulation AMPK/mTOR/ULK1 pathway.
A Distinct Expression Pattern of Cyclin K in Mammalian Testes Suggests a Functional Role in Spermatogenesis
It is suggested that cyclin K may be a novel molecular link between germ cell development, cancer development and embryonic stem cell maintenance.
Novel nano-microspheres containing chitosan, hyaluronic acid, and chondroitin sulfate deliver growth and differentiation factor-5 plasmid for osteoarthritis gene therapy
NMPs with excellent physicochemical and biological properties could be promising non-viral vectors for OA gene therapy and when injected into OA model rabbits, the expression of ECM proteins in chondrocytes was significantly promoted and the progression of OA was slowed down.
Regenerative Intervertebral Disc Endplate Based on Biomimetic Three-dimensional Scaffolds
A novel regenerative CEP is fabricated to support nutrients and metabolites exchange of IVD and shows features similar to its natural counterpart, and may play an important role in overall fabrication of regenerative IVD in near future.