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Involvement of Organic Anion-Transporting Polypeptides in the Hepatic Uptake of Dioscin in Rats and Humans
The results indicate that hepatic uptake of dioscin is involved in OATP1B3 in humans, and multiple Oatps might participate in this process in rats. Expand
Human transporters, PEPT1/2, facilitate melatonin transportation into mitochondria of cancer cells: An implication of the therapeutic potential
PEPT1/2 can potentially be used as a cancer cell‐targeted melatonin delivery system to improve the therapeutic effects of melatonin in cancer treatment and play a pivotal role in melatonin uptake in cells. Expand
Inhibitory Effects of Highly Oxygenated Lanostane Derivatives from the Fungus Ganoderma lucidum on P-Glycoprotein and α-Glucosidase.
In silico docking analysis suggested these compounds had similar P-gp recognition mechanisms compared with those of verapamil (a classical inhibitor), and in an in vitro bioassay, compounds 2, 4, 5, 6, and 18 showed moderate inhibitory effects against α-glucosidase compared withThose of the positive control acarbose. Expand
Salvianolic acid A preconditioning confers protection against concanavalin A-induced liver injury through SIRT1-mediated repression of p66shc in mice.
It is indicated that SalA may be a potent activator of SIRT and thatSalA can alleviate ConA-induced hepatitis through SIRT1-mediated repression of the p66shc pathway. Expand
Diterpenoids from the roots of Euphorbia fischeriana and their inhibitory effects on α-glucosidase
Three diterpenoids were obtained using various chromatographic techniques, and their structures were determined by spectroscopic data including HRESIMS, 1D N MR, 2D NMR, ECD, and calculated ECD which gave two new diterPenoids, daphnane type (1) and ent-pimarene type (3). Expand
Benzylpenicillin inhibits the renal excretion of acyclovir by OAT1 and OAT3.
It is indicated that acyclovir is a substrate for OAT1 and OAT3 in vivo and in vitro, and PCG inhibits the renal excretion of acyClovir by inhibiting renal transporters OAT 1 and Oat3 in vitro. Expand
OAT1 and OAT3: targets of drug-drug interaction between entecavir and JBP485.
  • Q. Xu, C. Wang, +6 authors K. Liu
  • Chemistry, Medicine
  • European journal of pharmaceutical sciences…
  • 12 March 2013
Entecavir and JBP485 (a dipeptide) exhibit the antihepatitis activities and it is possible for the two drugs to be coadministered in the treatment of hepatitis. We aimed to elucidate whetherExpand
Inhibition of HMGB1 release via salvianolic acid B-mediated SIRT1 up-regulation protects rats against non-alcoholic fatty liver disease
It is demonstrated that the SIRT1/HMGB1 pathway is a key therapeutic target for controlling NAFLD inflammation and that SalB confers protection against HFD- and PA-induced hepatic steatosis and inflammation through Sirtuin 1-mediated HMGB1 deacetylation. Expand
Gamabufotalin, a bufadienolide compound from toad venom, suppresses COX-2 expression through targeting IKKβ/NF-κB signaling pathway in lung cancer cells
This study provides pharmacological evidence that CS-6 exhibits potential use in the treatment of COX-2-mediated diseases such as lung cancer and induced apoptosis by activating the cytochrome c and caspase-dependent apoptotic pathway. Expand
Alantolactone, a natural sesquiterpene lactone, has potent antitumor activity against glioblastoma by targeting IKKβ kinase activity and interrupting NF-κB/COX-2-mediated signaling cascades
ATL exerts its anti-tumor effects in human GBM cells at least in part via NF-κB/COX-2-mediated signaling cascades by inhibiting IKKβ kinase activity. Expand