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Overexpression of HMGA2 Promotes Metastasis and Impacts Survival of Colorectal Cancers
Purpose: This study aims to address the hypothesis that the high-mobility group A2 (HMGA2), an oncofetal protein, relates to survivability and serves as a prognostic biomarker for colorectal cancer… Expand
Tumor-infiltrating CD39+ γδTregs are novel immunosuppressive T cells in human colorectal cancer
ABSTRACT Tumor microenvironment (TME) promotes immune suppression through recruiting and expanding suppressive immune cells such as regulatory T cells (Tregs) to facilitate cancer progression. In… Expand
Oncological role of HMGA2 (Review).
- Shizhen Zhang, Qiuping Mo, Xiaochen Wang
- Biology, Medicine
- International journal of oncology
- 1 October 2019
The high mobility group A2 (HMGA2) protein is a non‑histone architectural transcription factor that modulates the transcription of several genes by binding to AT‑rich sequences in the minor groove of… Expand
Downregulation of TRIM21 contributes to hepatocellular carcinoma carcinogenesis and indicates poor prognosis of cancers
The aim of our work is to clarify the clinical implication and functional role of tripartite motif 21 (TRIM21) in hepatocellular carcinoma (HCC). We validated that TRIM21 was downregulated in liver… Expand
Clinical implications of periostin in the liver metastasis of colorectal cancer.
- Guoqiang Wu, Xiaochen Wang, Xuefeng Zhang
- Cancer biotherapy & radiopharmaceuticals
- 13 May 2013
AIM To investigate the expression status of periostin in colorectal cancer (CRC) to lay a foundation for managing this disease. METHODS Periostin expression status was detected by… Expand
Overexpression of RRM2 decreases thrombspondin-1 and increases VEGF production in human cancer cells in vitro and in vivo: implication of RRM2 in angiogenesis
BackgroundIn addition to its essential role in ribonucleotide reduction, ribonucleotide reductase (RNR) small subunit, RRM2, has been known to play a critical role in determining tumor malignancy.… Expand
Ribonucleotide reductase small subunit M2 serves as a prognostic biomarker and predicts poor survival of colorectal cancers
The overexpression of RRM2 [RR (ribonucleotide reductase) small subunit M2] dramatically enhances the ability of the cancer cell to proliferate and to invade. To investigate further the relevance of… Expand
Distinct prognostic values of S100 mRNA expression in breast cancer
S100 family genes encode low molecular weight, acidic-Ca2+ binding proteins implicating in a wide spectrum of biological processes. S100 family contains at least 20 members, most of which are… Expand
Discovery of significant pathways in breast cancer metastasis via module extraction and comparison.
Discovering significant pathways rather than single genes or small gene sets involved in metastasis is becoming more and more important in the study of breast cancer. Many researches have shed light… Expand
Retrospective and comparative analysis of 99mTc-Sestamibi breast specific gamma imaging versus mammography, ultrasound, and magnetic resonance imaging for the detection of breast cancer in Chinese…
BackgroundDiagnosing breast cancer during the early stage may be helpful for decreasing cancer-related mortality. In Western developed countries, mammographies have been the gold standard for breast… Expand