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Mechanisms of AIF-Mediated Apoptotic DNA Degradation in Caenorhabditis elegans
WAH-1 associated and cooperated with the mitochondrial endonuclease CPS-6/endonuclease G (EndoG) to promote DNA degradation and apoptosis, which defines a single, mitochondria-initiated apoptotic DNA degradation pathway that is conserved between C. elegans and mammals. Expand
Endocytic Sorting and Recycling Require Membrane Phosphatidylserine Asymmetry Maintained by TAT-1/CHAT-1
A novel Caenorhabditis elegans Cdc50 family protein, CHAT-1, is identified, which acts as the chaperone of the Tat-1 P4-ATPase to regulate membrane phosphatidylserine (PS) asymmetry and endocytic transport. Expand
Cell Corpse Engulfment Mediated by C. elegans Phosphatidylserine Receptor Through CED-5 and CED-12
It is reported that psr-1, the Caenorhabditis elegans homolog of PSR, is important for cell corpse engulfment and suggests that PSR-1 is likely an upstream receptor for the signaling pathway containing CED-2, C ED-5,CED-10, and CED -12 proteins and plays an important role in recognizing phosphatidylserine during phagocytosis. Expand
Caenorhabditis elegans Myotubularin MTM-1 Negatively Regulates the Engulfment of Apoptotic Cells
It is proposed that MTM-1 negatively regulates cell corpse engulfment through the CED-5/CED-12/Ced-10 module by dephosphorylating PtdIns(3)P on the plasma membrane in vivo and loss of mtm-1 function accelerates the clearance of cell corpses by promoting their internalization. Expand
C. elegans mitochondrial factor WAH-1 promotes phosphatidylserine externalization in apoptotic cells through phospholipid scramblase SCRM-1
The development of an annexin V-based phosphatidylserine labelling method is reported and it is shown that a majority of apoptotic germ cells in Caenorhabditis elegans have surface-exposed phosphatido-serine, indicating that phosphate externalization is a conserved apoptotic event in worms. Expand
Sequential action of Caenorhabditis elegans Rab GTPases regulates phagolysosome formation during apoptotic cell degradation
The data reveal the sequential action of Rab GTPases in regulating tethering, docking, and fusion of lysosomes to apoptotic cell-containing phagosomes to regulate phagosome maturation. Expand
C. elegans Rab GTPase activating protein TBC-2 promotes cell corpse degradation by regulating the small GTPase RAB-5
It is proposed that TBC-2 functions as a GAP to cycle RAB-5 from an active GTP-bound to an inactive GDP-bound state, which is required for maintaining RAB -5 dynamics on phagosomes and serves as a switch for the progression of phagosome maturation. Expand
Autophagy genes function sequentially to promote apoptotic cell corpse degradation in the engulfing cell
  • Wei Li, Wei Zou, +7 authors G. Ou
  • Biology, Medicine
  • The Journal of cell biology
  • 2 April 2012
Autophagy genes are not only essential for exposing the engulfment signal on apoptotic cells but also function in phagocytes to promote apoptotic cell removal.
C. elegans Rab GTPase 2 is required for the degradation of apoptotic cells
The identification and characterization of unc-108, the Caenorhabditis elegans homolog of the human Rab GTPase 2, as a novel component involved in the degradation of apoptotic cells is reported. Expand
Role of C. elegans TAT-1 Protein in Maintaining Plasma Membrane Phosphatidylserine Asymmetry
Tat-1 appears to function in preventing appearance of PS in the outer leaflet of plasma membrane, and ectopic exposure of PS on the cell surface may result in removal of living cells by neighboring phagocytes. Expand