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We develop a model of friendship formation that sheds light on segregation patterns observed in social and economic networks. Individuals have types and see type-dependent benefits from friendships. We examine the properties of a steady-state equilibrium of a matching process of friendship formation. We use the model to understand three empirical patterns(More)
Studying growth and development of plants is of central importance in botany. Current quantitative are either limited to tedious and sparse manual measurements, or coarse image-based 2D measurements. Availability of cheap and portable 3D acquisition devices has the potential to automate this process and easily provide scientists with volumes of accurate(More)
Protein with tau-like repeats (PTL-1) is the sole Caenorhabditis elegans homolog of tau and MAP2, which are members of the mammalian family of microtubule-associated proteins (MAPs). In mammalian neurons, tau and MAP2 are segregated, with tau being mainly localised to the axon and MAP2 mainly to the dendrite. In particular, tau plays a crucial role in(More)
PTL-1 is the sole homolog of the MAP2/MAP4/tau family in Caenorhabditis elegans. Accumulation of tau is a pathological hallmark of neurodegenerative diseases such as Alzheimer's disease. Therefore, reducing tau levels has been suggested as a therapeutic strategy. We previously showed that PTL-1 maintains age-related structural integrity in neurons, implying(More)
It has recently been described that aging in C. elegans is accompanied by the progressive development of morphological changes in the nervous system. These include novel outgrowths from the cell body or axonal process, as well as blebbing and beading along the length of the axon. The formation of these structures is regulated by numerous molecular players(More)
1. This is a concise review of the field of ion pumping from the perspective of the authors. 2. The period covered spans the discovery of Na(+) and K(+) concentration gradients across animal cell membranes by Carl Schmidt in the 1850s, through the isolation of the Na(+) /K(+) -ATPase by Skou in 1957 (for which he was awarded the 1997 Nobel Prize in(More)
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