Xiaochang Zhang

Publications16
h-index8
Citations1,354
Highly Influential Citations113
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SUN1/2 and Syne/Nesprin-1/2 Complexes Connect Centrosome to the Nucleus during Neurogenesis and Neuronal Migration in Mice
Nuclear movement is critical during neurogenesis and neuronal migration, which are fundamental for mammalian brain development. Although dynein, Lis1, and other cytoplasmic proteins are known for… Expand
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Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation
Proper nuclear positioning is important to cell function in many biological processes during animal development. In certain cells, the KASH-domain-containing proteins have been shown to be associated… Expand
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SUN1 and SUN2 play critical but partially redundant roles in anchoring nuclei in skeletal muscle cells in mice
How the nuclei in mammalian skeletal muscle fibers properly position themselves relative to the cell body is an interesting and important cell biology question. In the syncytial skeletal muscle… Expand
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Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex
Alternative splicing is prevalent in the mammalian brain. To interrogate the functional role of alternative splicing in neural development, we analyzed purified neural progenitor cells (NPCs) and… Expand
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Mutations in QARS, encoding glutaminyl-tRNA synthetase, cause progressive microcephaly, cerebral-cerebellar atrophy, and intractable seizures.
Progressive microcephaly is a heterogeneous condition with causes including mutations in genes encoding regulators of neuronal survival. Here, we report the identification of mutations in QARS… Expand
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Rates, Distribution, and Implications of Post-zygotic Mosaic Mutations in Autism Spectrum Disorder
We systematically analyzed postzygotic mutations (PZMs) in whole-exome sequences from the largest collection of trios (5,947) with autism spectrum disorder (ASD) available, including 282 unpublished… Expand
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microRNAs play critical roles in the survival and recovery of Caenorhabditis elegans from starvation-induced L1 diapause
Environmental stresses and nutrition availability critically affect animal development. Numerous animal species across multiple phyla enter developmental arrest for long-term survival in unfavorable… Expand
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Somatic mutations in cerebral cortical malformations.
BACKGROUND Although there is increasing recognition of the role of somatic mutations in genetic disorders, the prevalence of somatic mutations in neurodevelopmental disease and the optimal techniques… Expand
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Nuclear Migration: Rock and Roll Facilitated by Dynein and Kinesin
The nucleus encounters other organelles as well as high cytoplasmic pressures during its migration within the cell. A new study describes how the action of kinesin and dynein motors is coordinated at… Expand
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Follicular Lymphoma Presenting With Monoclonal IgM And MYD88 Mutation: A Case Report And Review Of The Literature
Abstract MYD88 mutation has been reported in various lymphomas, specifically in lymphoplasmacytic lymphoma. Yet, the mutation has not been reported in primary follicular lymphoma. Here, we present a… Expand
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