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Interdisciplinary challenges in research today require increasingly cooperation among researchers. The demand for building up Virtual Research Environments (VRE) becomes more and more urgent than ever before. Built on top of web, VRE systems aim at supporting research activities with much more efficient methods for sharing data and knowledge bases. In this(More)
Species within the fungal genus Pestalotiopsis have become a topic of research in many microbial-chemical and pharmacological laboratories because they contain structurally complex, biologically active metabolites. This article is a follow-up to a previous review (Xu, Ebada, and Proksch, Fungal Divers 44:15–31, 2010). It focuses particularly on new findings(More)
BACKGROUND There is ample evidence that Hsp70 takes part in the progress of coronary heart disease (CHD). This implies that genetic variants of Hsp70 genes such as HSPA8 (HSC70) gene might contribute to the development of CHD. The present study aimed to investigate whether certain genetic variants of HSPA8 gene are associated with CHD in Han Chinese people.(More)
Our previous study has shown that reduced insulin resistance (IR) was one of the possible mechanisms for the therapeutic effect of silibinin on non-alcoholic fatty liver disease (NAFLD) in rats. In the present study, we investigated the pathways of silibinin in regulating hepatic glucose production and IR amelioration. Forty-five 4- to 6-week-old male(More)
BACKGROUND HSP70 plays crucial roles in endothelial cell apoptosis, which is involved in the early phase and progress of coronary heart disease (CHD). However, the association between polymorphisms of HSP70 genes and the risk of CHD still remains unclear. Our aim was to determine whether genetic variants in the HSPA1A gene are associated with the risk of(More)
BACKGROUND NBS1 is a key DNA repair protein in the homologous recombination repair pathway and a signal modifier in the intra-S phase checkpoint that plays important roles in maintaining genomic stability. The NBS1 8360G>C (Glu185Gln) is one of the most commonly studied polymorphisms of the gene for their association with risk of cancers, but the results(More)