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Aluminium chloride impairs long-term memory and downregulates cAMP-PKA-CREB signalling in rats.
Epidemiological investigations have indicated that aluminium (Al) is an important environmental neurotoxicant that may be involved in the aetiology of the cognitive dysfunction associated with… Expand
Lanthanum chloride impairs spatial learning and memory and downregulates NF-κB signalling pathway in rats
Exposure to rare earth elements (REEs) is known to impair intelligence in children and cause neurobehavioral abnormalities in animals. However, the mechanisms underlying these phenomena are not… Expand
A Systematic Review and Meta-Analysis of Epidemiology and Clinical Manifestations of Human Brucellosis in China
Background. Brucellosis has a wide spectrum of clinical manifestations and it may last several days or even several years; however, it is often misdiagnosed and therefore may cause inadequate therapy… Expand
Protective Role of tert-Butylhydroquinone Against Sodium Fluoride-Induced Oxidative Stress and Apoptosis in PC12 Cells
- J. Wu, M. Cheng, +6 authors Y. Cai
- Chemistry, Medicine
- Cellular and Molecular Neurobiology
- 25 April 2015
The neurotoxicity of fluoride is associated with oxidative stress due to imbalance between production and removal of reactive oxygen species (ROS). In contrast, induction of detoxifying and… Expand
MiR-124 Attenuates Osteoclastogenic Differentiation of Bone Marrow Monocytes Via Targeting Rab27a
- L. Tang, Yiran Yin, J. Liu, Z. Li, Xiaobo Lu
- Medicine, Biology
- Cellular Physiology and Biochemistry
- 18 October 2017
Background/Aims: With the aging population increases, senile osteoporosis has become a global public health problem. Previous evidence has shown that miR-124 has important effects on the occurrence… Expand
Prenatal and Lactational Lead Exposure Enhanced Oxidative Stress and Altered Apoptosis Status in Offspring Rats’ Hippocampus
Oxidative stress and apoptosis facilitation in the developing central nervous system (CNS) have been inferred as two mechanisms related to lead’s neurotoxicity, and excessive reactive oxygen species… Expand
Bone mesenchymal stem cell transplantation via four routes for the treatment of acute liver failure in rats
- L. Sun, X. Fan, +5 authors Y. Zhang
- International journal of molecular medicine
- 11 August 2014
In the present study, we assessed the efficiency of four BMSC transplantation methods as a therapy for liver failure. A rat model (80 Sprague-Dawley rats) of D-galactosamine… Expand
MiR-30a attenuates osteoclastogenesis via targeting DC-STAMP-c-Fos-NFATc1 signaling.
Osteoclast is a kind of unique cells which is responsible for bone matrix absorption. It was widely reported that microRNAs (miRNAs) could regulate several physiological processes, including… Expand
Conditioned medium from actinomycin D-treated apoptotic cells induces mitochondria-dependent apoptosis in bystander cells.
Chemical-induced bystander effects have been known for several years, but the underlying mechanism is still seldom investigated. Previous researchers have found that mitomycin C and phleomycin… Expand
Lanthanum chloride impairs memory in rats by disturbing the glutamate-glutamine cycle and over-activating NMDA receptors.
- X. Hu, J. Yang, +9 authors Y. Cai
- Chemistry, Medicine
- Food and chemical toxicology : an international…
Studies have reported that lanthanum chloride (LaCl3) can across the blood-brain barrier, accumulate in the brain and affect the spatial learning and memory abilities. However, the potential… Expand