Xiaobing Lin

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Mitochondrial DNA (mtDNA) mutations have been implicated in a broad range of disorders which severely affect human health (Wallace, 1999). Some drugs have been developed to slow down pathological changes of mitochon-drial disorders. However, there is no effective treatment for patients with mtDNA mutations. mtDNA is less protected and has fewer repair(More)
Induced pluripotent stem cells (iPSCs) have fewer and immature mitochondria than somatic cells and mainly rely on glycolysis for energy source. During somatic cell reprogramming, somatic mitochondria and other organelles get remodeled. However, events of organelle remodeling and interaction during somatic cell reprogramming have not been extensively(More)
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