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NAMPT inhibition sensitizes pancreatic adenocarcinoma cells to tumor-selective, PAR-independent metabolic catastrophe and cell death induced by β-lapachone

• Zachary Moore, Gaurab Chakrabarti, +7 authors David A. Boothman
• Cell Death and Disease
• 2015

Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors (e.g., FK866) target the most active pathway of NAD+ synthesis in tumor cells, but lack tumor-selectivity for use as a single agent. Reducing… (More)

CDK5 functions as a tumor promoter in human colorectal cancer via modulating the ERK5–AP-1 axis

• Kangmin Zhuang, Juchang Zhang, +7 authors Side Liu
• Cell Death and Disease
• 2016

Abnormal expression of cyclin-dependent kinase 5 (CDK5) has been found in several human cancers, whereas the role of CDK5 in the malignant development of colorectal cancer (CRC) has not been well… (More)

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