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OBJECTIVE This study was conducted to evaluate the efficacy of a "mini" version of the frameless intrauterine system (IUS; GyneFix), which has a copper surface area of approximately 200 mm(2). The small GyneFix version consists of four copper cylinders instead of six and is only 2 cm long. MATERIALS AND METHODS A total of 392 insertions were performed in(More)
OBJECTIVE To evaluate the feasibility and safety of retroperitoneal laparoendoscopic single-site adrenalectomy for pheochromocytoma (LESS-PHEO) and summarize our initial experience. PATIENTS AND METHODS Between June 2009 and June 2013, 21 patients with adrenal pheochromocytoma underwent adrenalectomy by means of LESS-PHEO in our department. Fifty-three(More)
BACKGROUND & AIMS Current stool DNA tests identify about half of individuals with colorectal cancers and miss most individuals with advanced adenomas. We developed a digital melt curve (DMC) assay to quantify low-abundance mutations in stool samples for detection of colorectal neoplasms and compared this test with other approaches. METHODS We combined a(More)
BACKGROUND Aberrantly methylated genes represent important markers for cancer diagnosis. We describe a multiplex detection approach to efficiently quantify these markers for clinical applications such as colorectal cancer screening. METHODS Quantitative allele-specific real-time target and signal amplification (QuARTS) combines a polymerase-based target(More)
Lung ischemia–reperfusion injury (LIRI) may occur in the region of the affected lung after reperfusion therapy. Inhaled NO may be useful in treating acute and chronic pulmonary thromboembolism (PTE) due to the biological effect property of NO. A PTE canine model was established through selectively embolizing blood clots to an intended right lower lobar(More)
an approach to design and analyze the learning support system based on "learning flow" has been presented from a new perspective according to the chronological processed characteristics with which the learning activities carry out. "Learning flow", inspired by the concept of the "workflow" technology, will be able to provide a new support structure for(More)
E74-like factor 5 (Elf5) has been associated with tumor suppression in breast cancer. However, its role in urothelial cancer (UC) is completely unknown. Immunohistochemistry (IHC) and methylation specific PCR (MSP) were done to detect Elf5 expression level and its promoter methylation. Results revealed that low expression of Elf5 on protein and mRNA levels(More)
Lung ischemia–reperfusion injury (LIRI) may occur in the region of the affected lung after reperfusion therapy. The inflammatory response mechanisms related to LIRI in pulmonary thromboembolism (PTE), especially in chronic PTE, need to be studied further. In a PTE model, inflammatory response and apoptosis may occur during LIRI and nitric oxide (NO)(More)
This study was conducted to evaluate the efficacy of a 'mini' version of the frameless intrauterine system (IUS) (GyneFix) that has a copper surface area of approximately 200 mm(2). The GyneFix-mini consists of four copper cylinders instead of six and is only 2 cm long. A total of 301 insertions were performed in an open nonrandomized pilot study in parous(More)
BACKGROUND Stool DNA testing in patients with inflammatory bowel disease (IBD) may detect colorectal cancer and advanced precancers with high sensitivity; less is known about the presence of DNA markers in small IBD lesions, their association with metachronous neoplasia, or contribution to stool test positivity. METHODS At a single center in 2 blinded(More)