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Atrial fibrillation (AF) is a common cardiac arrhythmia whose molecular etiology is poorly understood. We studied a family with hereditary persistent AF and identified the causative mutation (S140G) in the KCNQ1 (KvLQT1) gene on chromosome 11p15.5. The KCNQ1 gene encodes the pore-forming alpha subunit of the cardiac I(Ks) channel (KCNQ1/KCNE1), the(More)
An odorous tap water crisis that affected two million residents for several days occurred in Wuxi, China in the summer of 2007. Volatile sulfide chemicals including methyl thiols, dimethyl sulfide, dimethyl disulfide, and dimethyl trisulfide were the dominant odorous contaminants in Lake Taihu and in tap water during the crisis. These contaminants(More)
OBJECTIVE To investigate the possible association of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) promoter -1722 polymorphism with systemic lupus erythematosus (SLE) in the population in southern China. METHODS A total of 103 SLE patients (13 males and 90 females with an average age of 33.63+/-12.58 years) diagnosed according to the SLE diagnostic(More)
OBJECTIVE To understand the clinical features and prognosis of IgA nephropathy (IgAN) patients with glomerular crescents. METHODS The clinical data collected at the time of renal biopsy and the follow-up data of 89 IgAN patients with glomerular crescents were analyzed with 412 IgAN patients without crescents serving as the control group. Follow-up study(More)
Streptococcus pneumoniae is an important pathogen of pneumonia in human. Human alveolar epithelium acts as an effective barrier and is an active participant in host defense against invasion of bacterial by production of various mediators. Sirtuin 1 (SIRT1), the prototypic class III histone deacetylase, is involved in the molecular control of lifespans and(More)
The low frequency oscillatory flow in a rotating curved pipe was studied by using the method of biparameter perturbation. Perturbation solutions up to the second order were obtained and the effects of rotation on the low frequency oscillatory flow were examined in detail. The results indicated that there exists evident difference between the low frequency(More)
Diabetes mellitus is a common metabolic disease with a high and growing prevalence affecting 4% of the population worldwide, the development of safe and effective therapeutic drug is the major thrust for chemists and pharmacists. To search for active antidiabetic lead compound, we designed and synthesized some novel beta-amino ketone derivatives containing(More)
疫苗接种与乳酸链球菌素Z 治疗对泌乳期奶牛乳腺感染金黄色葡萄球菌的疗效研究 评价联合应用金黄色葡萄球菌疫苗接种和乳酸链 球菌素Z 治疗对乳腺隐性感染金黄色葡萄球菌奶 牛的治疗效果。 首次证明了金黄色葡萄球菌疫苗接种和乳酸链球 菌Z治疗对泌乳期奶牛乳腺金黄色葡萄球菌感染 的治疗效果。 将75 头乳腺隐性感染金黄色葡萄球菌的泌乳期 黑白花奶牛随机分为3 组:金黄色葡萄球菌疫苗 接种+乳酸链球菌素治疗组、乳酸链球菌素治疗 组和不治疗对照组。在治疗前和治疗后2、4 和 6 周,对无菌采集感染乳区奶样进行细菌学检查、 牛奶体细胞计数、N-乙酰-β-D-氨基葡萄糖苷酶 (NAGase)活性检测和牛奶品质(乳脂率和蛋白 率)检测。 和乳酸链球菌素单独治疗比较,金黄色葡萄球菌 疫苗接种联合乳酸链球菌素治疗显著降低了感(More)
AIMS To evaluate the adverse effect and survival outcome of weekly and triweekly cisplatin with radiotherapy in treatment of cervical cancer. METHODS After an extensive literature search between 1995-2011,we analyzed 7 studies to compare weekly cisplatin and triweekly cisplatin combined radiotherapy. RESULTS Our analysis established that weekly(More)