Xiao-wei Wei

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AIM To evaluate the diagnostic role of serum RASSF1A promoter hypermethylation in gastric and colorectal adenocarcinoma. METHODS Methylation-specific polymerase chain reaction (MSPCR) was used to examine the promoter methylation status of the serum RASSF1A gene in 47 gastric adenocarcinoma patients, 45 colorectal adenocarcinoma patients, 60 patients with(More)
The periostin protein, encoded by the POSTN gene, is a component of the extracellular matrix, which is expressed by fibroblasts and has been observed in a variety of human malignancies. The present study aimed to detect the expression of periostin in the tissues of non-small cell lung cancer (NSCLC) patients and benign lung tumors, and to correlate the(More)
Neural tube defects (NTDs) are severe congenital malformations that result from incomplete neurulation of the central nervous system. While collapsin response mediator protein 4 (CRMP-4) plays a critical role in the regulation of neurulation, information regarding the temporal expression of CRMP-4 during embryonic development of the spinal cord has yet to(More)
BACKGROUND A large number of studies have confirmed that excessive apoptosis is one of the reasons for deficient neuronal function in neural tube defects (NTDs). A previous study from our laboratory used 2-D gel electrophoresis to demonstrate that 14-3-3ζ expression was low in the spinal cords of rat fetuses with spina bifida aperta at embryonic day (E) 17.(More)
OBJECTIVE To investigate the effect of sFRP2 on the biological behavior of human hepatoma carcinoma HepG2 cells. METHODS HepG2 cells were infected with recombinant adenovirus containing mouse sFRP2 gene, and then the proliferation, cell cycle distribution, expression of tumor metastasis related factors (CD44, CD82/KAI1, EMMPRIN) and beta-catenin protein,(More)
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