Xiao-ming Yan

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OBJECTIVE To investigate the effect of lens opacity on the performance of the multi-focal visual evoked potential (mfVEP) test in patients with glaucoma and its relationship with the Humphrey's automated static perimetry. METHODS This is a prospective, non-randomized study. Twenty-two patients were enrolled with moderate cataract and primary glaucoma(More)
Meibomian gland dysfunction (MGD) is one of the most common diseases observed in clinics; it influences a great number of people, and is the leading cause of evaporative dry eye. Given the increased recognition of the importance of MGD, a great amount of attention has been paid to therapies targeting this condition. The traditional treatments of MGD consist(More)
PURPOSE To investigate the expression of mucin and inflammatory factors in the conjunctival epithelium of subjects with dry eye and determine a correlation between clinical laboratory tests and subjective symptoms. METHODS The ocular surface disease index questionnaire, corneal fluorescein staining, tear film breakup time, and Schirmer I tests were(More)
Zinc is an essential trace element for human growth and development. In this work, zinc-chelating peptides from rapeseed protein hydrolysates produced with alcalase were investigated by affinity chromatography with immobilized zinc and Sephadex G-25 gel filtration. Four small peptides, namely, Ala-Arg, Asn-Ser-Met (NSM), Gly-Lys-Arg, and Glu-Pro-Ser-His,(More)
We have developed a mold-to-mold cross imprint (MTMCI) process, which redefines an imprint mold with another imprint mold. By performing MTMCI on two identical imprint molds with silicon spacer nanowires in a perpendicular arrangement, we fabricated a large array of sub-30-nm silicon nanopillars. Large-area arrays of Pt dots are then produced using(More)
OBJECTIVE The aim of this study is to investigate the safety and efficiency of transducing human keratocytes with beta-galactosidase gene through cationic liposome and evaluate the influence of p21WAF1 gene transduction mediated by cationic liposome on proliferation of keratocyte. METHODS (1) Cationic liposome mediated plasmid DNA bearing(More)
PURPOSE To compare, in vivo, differences in meibomian gland morphology between children and adolescents. METHODS Sixty-nine patients were included in this study and divided into two groups: children (n = 31; age range: 3 to 11 years) and adolescents (n = 39; age range: 12 to 18 years). Images of meibomian glands were obtained by infrared meibography and(More)
Meibomian lipids are believed to compose the lipid layer of tear film and play important roles in maintaining the stability of tear film. Changes in composition of meibomian lipids contribute to the ocular surface disease, such as dry eye. The understanding of composition and role of meibomian lipids can help us understand the cause of these disease. This(More)
OBJECTIVE To observe the microstructure and cellular populations of normal human limbal and central corneas using laser confocal microscope. METHODS The study was consisted of 28 eyes of 15 examiners (age distribution, 16-61 years). After examinations with slit lamp biomicroscopy and ophthalmoscope, the images of superior, inferior limbus and central(More)
OBJECTIVE To investigate the cytotoxic effect of three kinds of topical ocular anti-allergic agent, including olopatadine 0.1% (A group), ketotifen fumarate 0.025% (B group) and pemirolast potassium 0.1% (C group), on cultured human corneal epithelial cells in vitro. METHODS Primary human corneal epithelial cells were cultured with keratinocyte serum-free(More)