Xiao-ling Yang

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Accumulating evidence has suggested that homocysteine (Hcy) is an independent risk factor for atherosclerosis (AS). Hcy can promote vascular smooth muscle cell (VSMC) proliferation, which is pivotal in the pathogenesis and progression of AS. The aim of the present study was to investigate the epigenetic regulatory mechanism of microRNA (miR)‑143‑mediated(More)
OBJECTIVE To investigate the health and nutrition status in middle-aged and old people in the urban district of Chongqing City, China in order to provide a rational diet construction for the population. METHOD This investigation was performed in 2004 and 1801 public officials both at post and retired in the urban district of Chongqinging City were(More)
Homocysteine (Hcy) is an independent risk factor for atherosclerosis, but the underlying molecular mechanisms are not known. We investigated the effects of Hcy on fatty acid-binding protein 4 (FABP4), and tested our hypothesis that Hcy-induced atherosclerosis is mediated by increased FABP4 expression and decreased methylation. The FABP4 expression and DNA(More)
AIM To look for the evidence of human papilloma virus (HPV) infection in esophageal squamous cell carcinomas (ESCC) and to investigate the potential role and epidemiology of HPV infection in the pathogenesis of esophageal carcinomas in Henan emigrants. METHODS Papilloma virus(PV) and HPV were determined by Ultrasensive S-P immunohistochemistry (IHC) and(More)
OBJECTIVE To describe the epidemiology of neural tube defects (NTDs) in high- and low-prevalence areas of China. METHODS Birth defects surveillance data, collected from 1992 through 1994 was analyzed. These data were collected as part of the Sino-American cooperative project on NTDs prevention. We classified NTDs as anencephaly, encephalocele, high-level(More)
OBJECTIVE To explore the epidemiological status of disabilities on vision impairment (VI), hearing loss (HL), mental retardation (MR), autism spectrum disorder (ASD) and motor disorder (MD) in aged 0-6 years old children in Beijing. METHODS A total of 28 738 children under 7 years old were recruited from permanent residents of Beijing City by 2-phase(More)
The aim of the present study is to explore the role of miR-124 and its promoter region DNA methylation in homocysteine (Hcy)-induced atherosclerosis. ApoE(-/-) mice were fed with hypermethionine diet for 16 weeks to duplicate hyperhomocysteinemia model. Meanwhile, a normal control group (C57BL/6J mice fed with normal diet, N-control) and a model control(More)
OBJECTIVE To investigate the current status of disabled children and prevalence of disabilities in children aged 0-6 years and their risk factors, and to provide scientific evidence for making relevant policies for disabled children. METHODS In a community-based cross-sectional study, multi-phase, stratified, unequal proportional and cluster sampling was(More)
OBJECTIVE To explore the effect of oxymatrine (OMT) on JAK2/STAT3 signaling in renal tissues of rats with septic shock. METHOD The cecal ligation and puncture (CLP) was adopted to establish the rat septic shock model. Fifty-six male SD rats were randomly divided into 7 groups: the sham operation group, the model (CLP) group, CLP + OMT high, middle,(More)
After two years continuous self-pollination,the variated specificities of five kinds of variations of maize induced by colchicine were examined and measured. Experiments show that germination potential increased 3% - 46%, cell diameter of root tip meristem region is 6% - 15% less than original material, meanwhile, nucleus diameter increased 5% - 18%,(More)