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Treatment of acute leukemia with unmanipulated HLA-mismatched/haploidentical blood and bone marrow transplantation.
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MRD-directed risk stratification treatment may improve outcomes of t(8;21) AML in the first complete remission: results from the AML05 multicenter trial.
TLDR
It is concluded that MRD status after the second consolidation may be the best timing for treatment choice, and risk-directed risk stratification treatment may improve the outcome of t(8;21) AML in CR1.
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Haploidentical vs identical-sibling transplant for AML in remission: a multicenter, prospective study.
TLDR
Unmanipulated haploidentical HSCT achieves outcomes similar to those of ISD HSCT for AML patients in CR1, and was demonstrated to be a valid alternative as postremission treatment of intermediate- or high-risk AMl patients inCR1 lacking an identical donor.
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Long‐term follow‐up of haploidentical hematopoietic stem cell transplantation without in vitro T cell depletion for the treatment of leukemia
TLDR
A new strategy was developed for HLA‐mismatched/haploidentical transplantation from family donors without in vitro T cell depletion (TCD) for patients who require allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
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Coinfusion of mesenchymal stromal cells facilitates platelet recovery without increasing leukemia recurrence in haploidentical hematopoietic stem cell transplantation: a randomized, controlled…
TLDR
An open-label, randomized phase II clinical study to assess the outcome of MSC coinfusion during haploidentical hematopoietic stem cell transplantation and found that within 100 days, the time to a platelet concentration of >50 × 10(9) cells/L was markedly faster in the treatment group compared with the control group.
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Who is the best donor for a related HLA haplotype-mismatched transplant?
TLDR
The data indicate which HLA haplotype-mismatched related donors are associated with the best transplant outcomes in persons with hematological neoplasms.
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Gasdermin E–mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome
TLDR
It is shown that tumor cell pyroptosis triggers CRS during CAR T cell therapy, and the quantity of perforin/granzyme B used by CAR T cells rather than existing CD8+ T cells is critical forCAR T cells to induce target cell pyproptosis.
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Haploidentical versus Matched-Sibling Transplant in Adults with Philadelphia-Negative High-Risk Acute Lymphoblastic Leukemia: A Biologically Phase III Randomized Study
TLDR
Haploidentical HSCT achieves outcomes similar to those of MSD-HSCT for Philadelphia-negative high-risk ALL patients in CR1, suggesting that such transplantation could be a valid alternative as post-remission treatment for high- risk ALL patientsin CR1 lacking an identical donor.
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Administration of imatinib after allogeneic hematopoietic stem cell transplantation may improve disease-free survival for patients with Philadelphia chromosome-positive acute lymphobla stic leukemia
TLDR
It is indicated that relapse rate can be reduced and DFS may be improved in Ph’+ ALL patients with imatinib maintenance therapy after HCT and BCR-ABL monitoring by qRT-PCR can guide maintenance therapy withImatinib including initiation time and treatment duration after allo-HCT.
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Haploidentical allograft is superior to matched sibling donor allograft in eradicating pre-transplantation minimal residual disease of AML patients as determined by multiparameter flow cytometry: a…
TLDR
For pre-MRD-positive AML patients, haplo-SCT was associated with lower incidence of relapse and better survival, suggesting a stronger anti-leukemia effect.
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