Xiao-hui Ren

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This study was designed to find whether long-term survivors (LTSs) exhibit molecular genetic differences compared with short-term survivors (STSs) in patients with GBM. Tumors from 12 patients initially diagnosed with GBM and survived longer than 36 months (LTSs) were compared with 30 patients with GBM and STSs (survival <18 months) for detecting of MGMT(More)
OBJECTIVE To project a new molecular classification system for anaplastic gliomas based on the molecular biomarkers. METHODS There were 161 patients with histological diagnosis of primary anaplastic gliomas after operation and complete and reliable follow-up data were enrolled in the study from May 2009 to June 2011. A total of 100 male and 61 female(More)
OBJECTIVE To explore the functions of NF2, TIMP-3 and THBS1 genes in the tumorigenesis or progression of meningiomas and analyze the values of these genes in early diagnosis, therapy and prognostic evaluation in meningiomas. METHODS A total of 66 cases with histological sections of meningiomas, including solitary (SMs, n = 30) and multiple meningiomas(More)
BACKGROUND Over past two decades, vagus nerve stimulation (VNS) has been widely used and reported to alleviate seizure frequency worldwide, however, so far, only hundreds of patients with pharmaco-resistant epilepsy (PRE) have been treated with VNS in mainland China. The study aimed to evaluate the effectiveness of VNS for Chinese patients with PRE and(More)
OBJECTIVES To find possible factors correlated with combined loss of heterozygosity (LOH) of 1p and 19q. METHODS The status of 1p and 19q of 138 glioma specimen from January 2009 to December 2009 was evaluated by Fluorescence in situ hybridization (FISH) method, and the frequencies of combining LOH of 1p/19q were compared between different pathologies,(More)
OBJECTIVE To investigate the frequencies of combining loss of heterozygosity (LOH) of chromosome 1p/19q in gliomas of different pathologies and analyze the clinical factors correlated with combining LOH by logistic regression. METHODS Tumor samples from 127 glioma patients were collected. The status of 1p and 19q was evaluated by fluorescence in situ(More)
OBJECTIVE To explore the clinical features, surgical approaches and outcomes of craniopharyngioma in adults. METHODS A total of 156 cases of adult craniopharyngioma underwent microsurgery at our hospital were retrospectively reviewed and classified into four types according to the location of tumor relative to sellar diaphragm and the third ventricle.(More)
OBJECT Intracranial epidermoid cysts are rare, potentially curable, benign lesions that are sometimes associated with severe postoperative complications, including hemorrhage. Delayed hemorrhage, defined as one that occurred after an initial unremarkable postoperative CT scan, contributed to most cases of postoperative hemorrhage in patients with epidermoid(More)
OBJECTIVE To analyze the features of isocitrate dehydrogenase 1 (IDH 1) mutation in 165 oligodendroglial tumors. METHODS IDH1 was detected in a series of 165 oligodendroglial paraffin specimens from 2009 to 2011. And their features were analyzed. RESULTS Mutant IDH1 was detected in 111 (67.3%) tumors including 109 (98.2%) CGT→CAT mutations, 1 (0.9%)(More)
OBJECTIVE To detect the expressions of matrix metalloproteinase-9(MMP-9), progesterone receptor(PR), Ki-67 and Survivin in the multiple meningiomas (MMs) and explore its genesis, diagnosis and bionomics features. METHODS A total of 66 cases with histological sections of meningiomas retrieved from the archives of Department of Pathology of our hospital,(More)