Xiao-fang Fan

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OBJECTIVE To study the effects of swimming exercise on the expression of apelin and its receptor (APJ) system in pulmonary tissues of rats with pulmonary hypertension induced by hypoxia. METHODS Forty-five male SD rats were randomly divided into control group, hypoxia group (seven-week) and swimming group (four-week swimming group after three-week(More)
The purpose of the present study was to explore the expression changes of intermedin/adrenomedullin 2 (IMD/ADM2), a novel small molecular bioactive peptide, and its receptors, calcitonin receptor-like receptor (CRLR) and receptor activity modifying proteins (RAMP1, RAMP2, RAMP3) in the right ventricle of rats with chronic hypoxia-induced pulmonary(More)
BACKGROUND Although the mechanisms and pathways mediating ARDS have been studied extensively, less attention has been given to the mechanisms and pathways that counteract injury responses. This study found that the apelin-APJ pathway is an endogenous counterinjury mechanism that protects against ARDS. METHODS Using a rat model of oleic acid (OA)-induced(More)
AIM To study the effect of curcumin on pulmonary arterial pressure and type I collagen of pulmonary arterioles in pulmonary hypertensive rats induced by chronic hypoxia and hypercapnia. METHODS Thirty six rats were randomly divided into three groups: normal control group (NC), hypoxic hypercapnic group (HH) and hypoxic hypercapnia + curcumin group (HC).(More)
The study was aimed to examine the effect of chronic intermittent hypoxia (CIH) on spatial memory of growing rats and to explore the possible underlying mechanisms. Sixty two rats were trained to perform the 8-arm radial maze task and were divided into four groups: 2-week-CIH (2IH) 2-week-control (2C) 4-week-CIH (4IH) and 4-week-control (4C). There were(More)
OBJECTIVE To investigate the effect of chronic hypoxia-hypercapnia and oxygen inhalation on L-arginine transport in rat pulmonary artery. METHODS Forty male Sprague-Dawley rats were randomly divided into four groups: normal control group (A), the group of 4-week hypoxia-hypercapnia after 4-week hypoxia (B), the group of 4-week oxygen inhalation (D) 4-week(More)
Along with the development of economy and society, type 2 diabetic mellitus (T2DM) has become one of the most common diseases at the global level. As one of the complications of T2DM, diabetic neuropathic pain (DNP) stubbornly and chronically affects the health and life of human beings. In the pain field, dorsal root ganglion (DRG) is generally considered(More)
AIM To study the effect of chronic hypoxic hypercapnia on expression of COX-2 mRNA in pulmonary arterioles. METHODS SD rats were randomly divided into two groups: control group and hypoxic hypercapnic group. COX-2 mRNA was observed in pulmonary arterioles by the technique of in situ hybridization. RESULTS mPAP, weight ratio of right ventricle (RV) to(More)
AIM To observe the expression of Urotensin II (U II) and its receptor (UT) on right ventricle in rats with chronic pulmonary hypertension induced by hypoxia and hypercapnia. METHODS Twenty male SD rats were randomly divided into normal control group (NC) and hypoxia-hypercapnia 4-week group(HH). Mean pulmonary arterial pressure(MPAP) and the weight ratio(More)
OBJECTIVE To study the role of apelin in the prevention of pulmonary hypertension induced by hypoxia in rats. METHODS The animal model of hypoxic pulmonary hypertension was established by exposing the rats to isobaric hypoxic chamber for 4 weeks (8 h/d, 6 d/ w). Forty male Sprague-Dawley rats were randomly divided into control group (NC), hypoxic(More)