Xiao-dong Sun

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AIM The mitotic kinesin Eg5 plays a critical role in bipolar spindle assembly, and its inhibitors have shown impressive anticancer activity in preclinical studies. This study was undertaken to investigate the effect of dimethylenastron, a specific inhibitor of Eg5, on the migration and invasion of pancreatic cancer cells. METHODS Human pancreatic cancer(More)
Chemotherapy drugs themselves may act as stressors to induce adaptive responses to promote the chemoresistance of cancer cells. Our previous research showed that sirtuin 1 (SIRT1) was overexpressed in pancreatic cancer patients and deregulation of SIRT1 with RNAi could enhance chemosensitivity. Thus, we hypothesized that SIRT1 might facilitate(More)
Axonal tracing is useful for detecting optic nerve injury and regeneration, but many commonly used methods cannot be used to observe axoplasmic flow and synaptic transmission in vivo. Manganese (Mn(2+))-enhanced magnetic resonance imaging (MEMRI) can be used for in vivo longitudinal tracing of the visual pathway. Here, we explored the dose response and time(More)
OBJECTIVE To study the neuroprotection by nerve growth factor (NGF) in retina in experimental retinal detachment (RD). METHODS Thirty one Sprague-Dawley rats were used as RD animal model by injected 0.1% sodium hyaluronate into the sub-neuroretina space. Those rats were divided into NGF experimental group, placebo group, normal control groups and(More)
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