Xiao-chun Min

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OBJECTIVE To investigate the spontaneous YMDD mutation rate. METHODS Serum samples collected from 196 untreated chronic HBV patients were detected by primer-specific real-time PCR. RESULTS Among 196 patients, spontaneous YMDD variants were detected in 21 subjects (20 YVDD mutants and 1 YIDD mutant). YMDD variants account for more than 50%, 25% to 50%,(More)
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