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Up regulation of interleukin-8 expressions induced by mast cell tryptase via protease activated receptor-2 in endothelial cell line.
TLDR
It is shown that protein and mRNA of protease activated receptor-2 could be expressed in ECV304 cells, and tryptase upregulated the expression levels of both interleukin-8 mRNA and protein. Expand
SAHA-based novel HDAC inhibitor design by core hopping method.
TLDR
This work provided an approach to design novel high-efficiency HDAC inhibitors with better ADMET properties and molecular dynamics simulation of the representative compound 101 was performed to study the stability of HDAC8-inhibitor system. Expand
Novel Inhibitor Design for Hemagglutinin against H1N1 Influenza Virus by Core Hopping Method
TLDR
It has been shown through the subsequent molecular docking studies and molecular dynamic simulations that Neo6 not only assumes more favorable conformation at the binding pocket of HA but also has stronger binding interaction with its receptor. Expand
Effects of IL-1β on the proliferation and apoptosis of gastric epithelial cells and acid secretion from isolated rabbit parietal cells.
TLDR
It is demonstrated that IL-1β plays a significant role in H. pylori-induced gastric carcinogenesis through 2 main mechanisms: i) IL- 1β may interfere in gastric epithelial cell growth by upregulating COX-2 expression; ii) IL-1 β may inhibit the acid secretion from parietal cells by downregulating H+/K+ATPase expression. Expand
Zinc finger protein HZF1 promotes K562 cell proliferation by interacting with and inhibiting INCA1.
TLDR
The results identified novel functions of the HZF1 gene and revealed a possible mechanism through which HZf1 affects K562 cell proliferation and apoptosis. Expand
Agonist and antagonist recognition studies for oestrogen receptor by molecular dynamics simulation
Oestrogen receptor (ER) is a ligand-activated transcription factor which plays an important role in many physiological processes. The aim of this study was to explore the difference between agonistExpand
Identification of the Trans-Activation Domain and the Nuclear Location Signals of Human Zinc Finger Protein HZF1 (ZNF16)
TLDR
This study approved that HZF1 solely could activate lacZ reporter gene in yeast host Y190 and identified three nuclear location signals, which were located in the regions of amino acids 255–280, 328–360, and 460–490, respectively, and all of them within the zinc finger region. Expand
[Effects of Helicobacter pylori and Helicobacter pylori-related cytokines on apoptosis of gastric epithelial cells and mechanisms thereof].
TLDR
The gastric epithelium apoptosis induced by H. pylori may be in association with Fas receptor, and IL-8 may enhance the H.pylori-induced apoptosis by up-regulating the Fas receptor expression. Expand
Apocynin attenuates oxidative stress and cardiac fibrosis in angiotensin II-induced cardiac diastolic dysfunction in mice
TLDR
The beneficial effects of apocynin on myocardial oxidative stress and cardiac fibrosis might be mediated partly through a pathway involving NADPH oxidase and OPN. Expand
Tranilast stabilizes the accumulation and degranulation of resident mast cells while reducing cardiomyocyte apoptosis in a swine model of coronary microembolisation
TLDR
This work investigated whether the MC stabilizer tranilast suppresses the accumulation and degranulation of MC while reducing cardiomyocyte apoptosis after CME. Expand
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