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BACKGROUND Bisphenol A (BPA) and 4-tertiary-octylphenol (tOP) are industrial chemicals used in the manufacture of polycarbonate plastics and epoxy resins (BPA) and nonionic surfactants (tOP). These products are in widespread use in the United States. OBJECTIVES We aimed to assess exposure to BPA and tOP in the U.S. general population. METHODS We(More)
BACKGROUND Many phthalates and phenols are hormonally active and are suspected to alter the course of development. OBJECTIVE We investigated prenatal exposures to phthalate and phenol metabolites and their associations with body size measures of the infants at birth. METHODS We measured 5 phenol and 10 phthalate urinary metabolites in a multiethnic(More)
OBJECTIVE We previously demonstrated that exposure to polyvinyl chloride plastic medical devices containing di(2-ethylhexyl) phthalate (DEHP) was associated with higher urinary concentrations of several DEHP metabolites in 54 premature infants in two neonatal intensive care units than in the general population. For 42 of these infants, we evaluated urinary(More)
BACKGROUND Prenatal bisphenol A (BPA) exposure may be associated with developmental toxicity, but few studies have examined the variability and predictors of urinary BPA concentrations during pregnancy. OBJECTIVE Our goal was to estimate the variability and predictors of serial urinary BPA concentrations taken during pregnancy. METHODS We measured BPA(More)
BACKGROUND Data concerning the effects of prenatal exposures to phthalates and phenols on fetal growth are limited in humans. Previous findings suggest possible effects of some phenols on male birth weight. OBJECTIVE Our aim was to assess the relationships between prenatal exposures to phthalates and phenols and fetal growth among male newborns. METHODS(More)
BACKGROUND Prenatal exposure to bisphenol A (BPA) increases offspring aggression and diminishes differences in sexually dimorphic behaviors in rodents. OBJECTIVE We examined the association between prenatal BPA exposure and behavior in 2-year-old children. METHODS We used data from 249 mothers and their children in Cincinnati, Ohio (USA). Maternal urine(More)
BACKGROUND Triclosan is a synthetic chemical with broad antimicrobial activity that has been used extensively in consumer products, including personal care products, textiles, and plastic kitchenware. OBJECTIVES This study was designed to assess exposure to triclosan in a representative sample > or = 6 years of age of the U.S. general population from the(More)
BACKGROUND Bisphenol A (BPA) is used to manufacture polymeric materials, such as polycarbonate plastics, and is found in a variety of consumer products. Recent data show widespread BPA exposure among the U.S. population. OBJECTIVE Our goal in the present study was to determine the temporal variability and predictors of BPA exposure. METHODS We measured(More)
Prenatal exposure to endocrine disruptors has the potential to impact early brain development. Neurodevelopmental toxicity in utero may manifest as psychosocial deficits later in childhood. This study investigates prenatal exposure to two ubiquitous endocrine disruptors, the phthalate esters and bisphenol A (BPA), and social behavior in a sample of(More)
BACKGROUND Maternal urinary biomarkers are often used to assess fetal exposure to phenols and their precursors. Their effectiveness as a measure of exposure in epidemiological studies depends on their variability during pregnancy and their ability to accurately predict fetal exposure. OBJECTIVES We assessed the relationship between urinary and amniotic(More)