Xiao Wen Wang

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BACKGROUND Germline mutations in PALB2 gene make a small contribution to heritable breast cancer susceptibility. A recent report has revealed that women with mutations in the PALB2 gene were more than nine times as likely to develop breast cancer compared to those without. The aim of this study is to understand the status of PALB2 mutations among Chinese(More)
OBJECTIVE To quantitate corneal keratocyte loss and repopulation of anterior stroma after de-epithelialization. METHODS Fourteen white New Zealand rabbits, each weighing 2.3 to 3.2 kg, were divided into seven groups. Each rabbit underwent a bilateral 6-mm mechanical deepithelialization procedure. The rabbits were killed two at a time after 1, 3, 6, 8, 10,(More)
Manual removal of the corneal epithelium currently precedes excimer laser photorefractive keratectomy. To assess the smoothness of the corneal surface following this procedure, six paired human eye-bank eyes (12 eyes) were manually deepithelialized using a blunt instrument (Paton spatula) on one eye and a sharp instrument (surgical blade) on the(More)
The purpose of this study was to determine whether the DNA of mitotic cells in the corneal and conjunctival epithelium can be labeled with 5-bromo-2-deoxyuridine (BrdU) immunostaining. Both corneas of four New Zealand white rabbits were deepithelialized in the center and the regenerated epithelium was evaluated for mitosis at 1, 3, 6, and 10 days. Unwounded(More)
PURPOSE To determine whether photorefractive keratectomy can be performed at lower energies than are currently employed in clinical trials. METHODS Fresh pig corneas were ablated using a clinical excimer laser to study the effects of various energy densities (100-200 mJ/cm2) and beam diameters on ablation rates and on the surface ultrastructure of the(More)
PURPOSE To evaluate the ability of topical diclofenac to decrease corneal opacity after excimer laser photorefractive keratectomy (PRK). METHODS Twenty New Zealand white rabbits underwent a unilateral 193-nm excimer laser myopic photorefractive keratectomy to correct 5 diopters. There were four groups of five rabbits each. The first group of rabbits(More)
OBJECTIVE To compare the effects of blowing dry (nitrogen or helium) and humidified gases over the corneal surface during photorefractive keratectomy. METHODS Excimer laser myopic ablations were performed on porcine eyes (10 per group) using humidified and dry nitrogen and helium gas under ambient conditions. Surface smoothness was quantified with light(More)
We investigated the effects of artificial tears on cultured rabbit and human keratocytes in vitro. The cells were exposed to seven nonpreserved commercially available artificial tear formulations and examined under phase-contrast microscopy for 60 min. After 5-min exposures to the solutions, rabbit keratocytes were fixed for transmission electron microscopy(More)
PURPOSE This study sought to determine whether pre- and posttreatment with topical diclofenac sodium 0.1% eye drops suppresses corneal inflammation after 193-nanometer excimer laser corneal ablation more effectively than does posttreatment alone. METHODS Eight rabbits were divided into four groups. Animals in group I were treated with topical diclofenac(More)
OBJECTIVE To determine if excimer laser myopic ablation with a defocused laser image produces a smoother ablation profile than does focused laser light. METHODS An ArF excimer laser was used to ablate a 5.00-diopter myopic correction in test blocks using both a contracting and expanding iris aperture. Defocused ablation was performed using a contracting(More)