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We comment on the flexibility profiles calculated by Zeng et al., and show that these profiles do not represent the local flexibility of the DNA molecule. If one takes into account the physics of elasticity, the averaged flexibility profile show an additional peak which is missed in the original calculation. We show that it is not possible to calculate the(More)
Many cellular processes exhibit periodic behaviors. Hence, one of the important tasks in gene expression data analysis is to detect subset of genes that exhibit cyclicity or periodicity in their gene expression time series profiles. Unfortunately, gene expression time series profiles are usually of very short length, with very few periods, irregularly(More)
The expectation-maximization (EM) algorithm can compute the maximum-likelihood (ML) or maximum a posterior (MAP) point estimate of the mixture models or latent variable models such as latent Dirichlet allocation (LDA),which has been one of the most popular probabilistic topic modeling methods in the past decade. However, batch EM has high time and space(More)